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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory
Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic...
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Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning/memory impairments in D-galactose-induced aging rats
Physical exercise reduces the effects of aging and cognitive decline by improving synaptic plasticity and spatial learning. However, the underlying...
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Astrocytes: The Rising Stars that Regulate Synaptic Plasticity and Long-Term Memory Formation
For decades, our understanding of the mechanisms underlying long-term synaptic plasticity and memory is largely limited to the roles played by...
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Random fluctuations and synaptic plasticity enhance working memory activities in the neuron–astrocyte network
Random fluctuations are inescapable feature in biological systems, but appropriate intensity of randomness can effectively facilitate information...
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Effectiveness of coenzyme Q10 on learning and memory and synaptic plasticity impairment in an aged Aβ-induced rat model of Alzheimer’s disease: a behavioral, biochemical, and electrophysiological study
RationaleAging is the major risk factor for Alzheimer’s disease (AD), and cognitive and memory impairments are common among the elderly....
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Restoring Synaptic Function: How Intranasal Delivery of 3D-Cultured hUSSC Exosomes Improve Learning and Memory Deficits in Alzheimer’s Disease
Memory problems are often the first signs of cognitive impairment related to Alzheimer’s disease (AD), and stem cells and stem cell-derived exosomes...
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Metaplasticity and Synaptic Tag and Capture: Differential Dynamics of Plasticity Regulation in the Hippocampus
Synaptic plasticity is a critical underlying mechanism of learning and memory. There is extensive evidence that neural activity at one point in time...
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Dopamine and Synaptic Tagging and Capture: A Neuromodulatory Interplay That Shapes Associative Plasticity
Dopamine is a neurotransmitter that plays a crucial role in regulating diverse functions, such as motor control, mood, sleep, attention, reward...
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Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene transcription. It is generally accepted that E–TC makes...
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Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
BackgroundThe amyloid- β (A β ) cascade is one of the most studied theories linked to AD. In multiple models, A β accumulation and dyshomeostasis have...
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TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology
Synapses are bridges for information transmission in the central nervous system (CNS), and synaptic plasticity is fundamental for the normal function...
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A Ketogenic Diet may Improve Cognitive Function in Rats with Temporal Lobe Epilepsy by Regulating Endoplasmic Reticulum Stress and Synaptic Plasticity
A ketogenic diet (KD) is often used in the treatment of refractory epilepsy. Many studies have found that it also has a positive impact on cognitive...
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Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism
Aluminum, an environmentally abundant non-redox trivalent cation, has long been reported to alter blood-brain barrier and gets deposited in different...
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Cholecystokinin Signaling can Rescue Cognition and Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease
Synaptic impairment and loss are an important pathological feature of Alzheimer's disease (AD). Memory is stored in neural networks through changes...
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Artemisin and human endometrial-derived stem cells improve cognitive function and synaptic plasticity in a rat model of Alzheimer disease and diabetes
Alzheimer disease (AD) is a common form of dementia associated with loss of memory and disruption of synaptic plasticity. There is a strong...
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Protective effects of docosahexaenoic acid supplementation on cognitive dysfunction and hippocampal synaptic plasticity impairment induced by early postnatal PM2.5 exposure in young rats
PM2.5 exposure is a challenging environmental issue that is closely related to cognitive development impairment; however, currently, relevant means...
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Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells
BackgroundThe over-activation of adenosine A 2A receptors (A 2A R) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing...
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Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture
Humans are commonly exposed to the representative neurotoxic heavy metals lead (Pb), cadmium (Cd), and mercury (Hg). These three substances can be...
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Hexahydrocurcumin Attenuates Neuronal Injury and Modulates Synaptic Plasticity in Chronic Cerebral Hypoperfusion in Rats
Dementia is the most common age-related problem due predominantly to Alzheimer’s disease (AD) and vascular dementia (VaD). It has been shown that...
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Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy
Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson’s disease. α-synucleinopathy in the...
