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LCM-Seq for Retinal Cell Layer-Specific Responses During Optic Nerve Regeneration
LCM-seq is a powerful tool for gene expression analysis from individual or groups of cells that can be spatially isolated. Within the visual system,...
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A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex
The cat primary visual cortex (V1) is a cortical area for which we have one of the most detailed estimates of the connection ‘weights’ (expressed as...
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Progression of Retinal Ganglion Cell and Nerve Fiber Layer Loss in Spinocerebellar Ataxia 3 Patients
Spectral domain optical coherence tomography (SD-OCT) allows noninvasive measurements of retinal neuron layers. Here, we evaluate the relationship...
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Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography
Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple...
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Co-culture of Two Different Cell Lines in a Two-Layer Microfluidic Device
Microfluidic devices have become a promising alternative approach for cellular co-culture. Many approaches incorporate a semipermeable barrier to...
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The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals
BackgroundTo evaluate a wide range of optical coherence tomography (OCT) parameters for possible application as a screening tool for cognitively...
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Microvascular Endothelial Glycocalyx Surface Layer Visualization and Quantification
As a primary interface between the blood and underlying vascular wall, the endothelial glycocalyx layer is common to all blood vessels and covers the...
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Single-Cell Ca2+ Imaging
In rheumatological studies, visualization of Ca2+ dynamics in intact cells as direct experimental evidence of Ca2+-dependent signal pathways is...
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BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely controlled process, with the...
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Colon-Targeted Layer-by-Layer Self-assembled Film: Pharmacokinetic Analysis of BCS Class I and Class III Model Drugs
The aim of the study was to investigate the pharmacokinetic parameters of 5-fluorouracil (5FU) and moxifloxacin HCl (MF) after oral administration...
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Multimodal cortical neuronal cell type classification
Since more than a century, neuroscientists have distinguished excitatory (glutamatergic) neurons with long-distance projections from inhibitory...
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Nano-optogenetic CAR-T Cell Immunotherapy
Chimeric antigen receptor (CAR)-T cell immunotherapy emerges as an effective cancer treatment. However, significant safety concerns remain, such as...
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Rapid Screening of CAR T Cell Functional Improvement Strategies by Highly Multiplexed Single-Cell Secretomics
The functional fitness of CAR T cells plays a crucial role in determining their clinical efficacy. Several strategies are being explored to increase...
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Cell Junctions and the Mechanics of Hair Cell Regeneration
Hundreds of millions of people worldwide have disabling hearing loss or imbalance. A major cause of these impairments is sensory hair cell loss from...
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Culture of Continuous Cell Lines
This chapter describes the culture of various continuous cell lines. Continuous cell lines are generated either due to specific genetic or epigenetic...
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Predicting breast cancer drug response using a multiple-layer cell line drug response network model
BackgroundPredicting patient drug response based on a patient’s molecular profile is one of the key goals of precision medicine in breast cancer...
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Interfaces to Control Cell-Biomaterial Adhesive Interactions
Cell adhesion to adsorbed proteins and adhesive sequences engineered on surfaces is crucial to cellular and host responses to implanted devices,...
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Stem Cell Culture from Embryos
Embryonal carcinoma cells were firstly used as the in vitro model for early mouse development because the morphology and pluripotency are similar...
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Mammalian Cell Culture: An Overview
The mammalian body typically consists of trillions of cells. These cells are the basic structural and functional units of a mammalian body. Together,...
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Troubleshooting of Mammalian Cell Culture
Physiologically, healthy culture of cells is the basic need of present mammalian cell culture. During mammalian cell culture, the engaged laboratory...