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Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
BackgroundBreast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances,...
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Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile
ObjectiveHuman hair follicles (HFs) are populated by a rich and diverse microbiome, traditionally evaluated by methods that inadvertently sample the...
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Laser Capture Microdissection of Vascular Endothelial Cells from Frozen Heart Tissues
Laser capture microdissection (LCM) enables researchers to selectively evaluate gene expression profiling of a specific cell type within a tissue....
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Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtype
BackgroundCombined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and...
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Gene Expression Analysis of Laser-Captured Purkinje Cells in the Essential Tremor Cerebellum
Essential tremor (ET) is a common, progressive neurological disease characterized by an 8–12-Hz kinetic tremor. Despite its high prevalence, the...
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Correlative Imaging to Detect Rare HIV Reservoirs and Associated Damage in Tissues
Correlative light-electron microscopy (CLEM) has evolved in the last decades, especially after significant developments in sample preparation,...
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Isolation and Purification of Various Mammalian Cells: Single Cell Isolation
A typical adult mammalian body consists of 30–40 trillion cells. Mammalian cells differ in their shape, size, morphology, and other structural and...
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Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection
ObjectiveWe aimed to reveal a spatial proteomic and immune signature of kidney function regions in lupus nephritis (LN).
Material and methods ...
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Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
ObjectiveTumors are heterogeneous three-dimensional masses populated by numerous cell types, including distinct sub-clones of cancerous cells....
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LCM-Seq for Retinal Cell Layer-Specific Responses During Optic Nerve Regeneration
LCM-seq is a powerful tool for gene expression analysis from individual or groups of cells that can be spatially isolated. Within the visual system,...
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Role of Myeloperoxidase in ROS Generation and Inflammation Response on Prostate Epithelial Cells
Myeloperoxidase (MPO) has been reported in prostate tissue, and considering its pro-oxidant properties, this location might be linked to prostate...
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Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus
Recently, it has become a consensus that systemic decreases in NAD + are a critical trigger for age-associated functional decline in multiple tissues...
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Fear Conditioning Leads to Enduring Alterations in RNA Transcripts in Hippocampal Neuropil that are Dependent on EphB2 Forward Signaling
Alterations in mRNA transcription have been associated with changes in brain functions. We wanted to examine if fear conditioning causes long-term...
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Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Acquired sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) both feature accumulation of nemaline rods in muscle...
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Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain
We have reported that the transcription factor Olig2 labels a subpopulation of astrocytes (Olig2-astrocytes), which show distribution patterns...
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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils
Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both...
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Somatic PDGFRB activating variants promote smooth muscle cell phenotype modulation in intracranial fusiform aneurysm
BackgroundThe fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants...
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Single-Cell Proteome Profiling of Neuronal Cells
Characterizing neuronal heterogeneity at the single-cell level can improve our understanding of developmental and disease processes and lead to novel...
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Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle
It is generally accepted that carnosine (β-alanyl- l -histidine) content is higher in glycolytic than in oxidative muscle fibres, but the underlying...
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The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study
Breast cancer in young patients is known to exhibit more aggressive biological behavior and is associated with a less favorable prognosis than the...
