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Laboratory Evaluation of Thrombophilia
Venous thromboembolism (VTE) occurs typically in the veins of the lower extremities and/or as pulmonary embolism. There is a myriad of causes of VTE...
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Establishment of a Cell Culture Laboratory
The present chapter describes the design of a mammalian cell culture laboratory equipped for scientific research purposes. In addition to the main...
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Laboratory Diagnosis of Bacterial Diseases
The clinical manifestations of bacterial diseases may be non-specific and protean. Nevertheless, they provide a clue in the diagnosis of bacterial...
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Laboratory Diagnosis of Viral Diseases
The clinical manifestations may be protean and nonspecific for many of the viral infections. However, they provide a clue in diagnosing viral...
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A pseudo-outbreak of MRSA due to laboratory contamination related to MRSA carriage of a laboratory staff member
BackgroundMethicillin resistant Staphylococcus aureus (MRSA) is a major burden for hospitals globally. However, in the Netherlands, the MRSA...
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Laboratory Diagnosis of HEV Infection
Serological and nucleic acid tests for detecting hepatitis E virus (HEV) have been developed for both epidemiologic and diagnostic purposes. The...
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Laboratory Animals
Though the current modern era has introduced equivalent alternatives for animal research like in-silico, in-vitro methods, and...
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Mammalian Cell Culture Laboratory: Equipment and Other Materials
This chapter describes all the instruments necessary to work in a cell culture laboratory safely and effectively, including the maintenance and...
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Good Laboratory Practice
Good Laboratory Practice (GLP) is defined as ‘a quality system concerned with the organisational process and the conditions under which non-clinical...
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Mpox: a review of laboratory detection techniques
Mpox (formerly monkeypox) is a zoonotic disease caused by monkeypox virus (MPXV), which, like smallpox, is characterised by skin rashes. While the...
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Fear Conditioning in Laboratory Rodents
An animal’s ability to avoid threat by learning about cues and places that predict the occurrence of a threat is pivotal for survival. This learning...
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Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure
BackgroundLymphocytic choriomeningitis virus (LCMV) is a human pathogen naturally present in wild rodents. In addition, LCMV is routinely used in...
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An Overview of Laboratory Testing for Antiphospholipid Antibodies
Antiphospholipid antibodies (aPL) represent a group of autoantibodies directed against phospholipids. These antibodies may arise in a number of...
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An Overview of Laboratory Testing for ADAMTS13
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) is also called von Willebrand factor (VWF) cleaving...
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Good Laboratory Practices
The potential risks associated with any microbiology laboratory are from handling infectious agents in addition to other hazards posed by use of...
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Role of the Laboratory in the Diagnosis of Poxvirus Infections
Although WHO-led global efforts led to eradication of smallpoxSmallpox over four decades ago, other poxvirusesPoxvirus, especially monkeypoxMonkeypox...
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Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis
As children develop paucibacillary forms of tuberculosis (TB), bacteriological tests usually are negative. This chapter describes aspects of the...
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Comparison of laboratory-based and non-laboratory-based WHO cardiovascular disease risk charts: a population-based study
BackgroundDetermining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions in high-risk groups. However,...
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Laboratory Markers of COVID-19 in the Emergency Room
After the December 2019 outbreak in China, infection by the novel Coronavirus SARS-Cov2 (COVID-19) has quickly overflowed worldwide. Different...