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Changes of Pulmonary Microhemodynamics in Experimental Pulmonary Thromboembolism after Pretreatment with K-Channel Activators
Changes in pulmonary microhemodynamics in response to pulmonary embolism under conditions of activation of K ATP channels with nicorandil, Kv channels...
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The Voltage-Gated Potassium Channel Kv2.1 as a Multicellular Drug Target
Voltage-gated potassium (K+; Kv) channels are critical homeostatic regulators of ionic equilibrium. The diversity of channel subtypes and expression...
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Peptide Toxins Targeting KV Channels
A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+...
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Desflurane improves electrical activity of neurons and alleviates oxygen–glucose deprivation-induced neuronal injury by activating the Kcna1-dependent Kv1.1 channel
Several volatile anesthetics have presented neuroprotective functions in ischemic injury. This study investigates the effect of desflurane (Des) on...
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Study on mechanical properties of dual-channel cryogenic 3D printing scaffold for mandibular defect repair
Mandibular defect repair has always been a clinical challenge, facing technical bottleneck. The new materials directly affect technological...
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Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts
Traumatic brain injury (TBI) and repetitive head impacts can result in a wide range of neurological symptoms. Despite being the most common...
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Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems
Hv1 is the only voltage-gated proton-selective channel in mammalian cells. It contains a conserved voltage-sensor domain, shared by a large class of...
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Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy
Epilepsy is a chronic brain disease that makes serious cognitive and motor retardation. Ion channels affect the occurrence of epilepsy in various...
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Inhibitory effects of N-methyl-D-aspartate (NMDA) and α1-adrenergic receptor antagonist ifenprodil on human Kv1.5 channel
Ifenprodil has been known to reduce cardiac contractility and cerebral vasodilation by antagonizing α 1 -adrenergic and N-methyl D-aspartate...
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Cell-Based hERG Channel Inhibition Assay in High-Throughput Format
Human ether-a-go-go-related gene (hERG) channel plays an essential role in the repolarization of the cardiac action potential. Genetic mutations and...
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Epigenetics Involvement in Oxaliplatin-Induced Potassium Channel Transcriptional Downregulation and Hypersensitivity
Peripheral neuropathy is the most frequent dose-limiting adverse effect of oxaliplatin. Acute pain symptoms that are induced or exacerbated by cold...
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Potential Benefit of Channel Activators in Loss-of-Function Primary Potassium Channelopathies Causing Heredoataxia
Potassium channels (KCN) are transmembrane complexes that regulate the resting membrane potential and the duration of action potentials in cells. The...
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Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
Transient receptor potential (TRP) channels are important in the sensing of pain and other stimuli. They may be triggered by electrophilic agonists...
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Triclosan is a KCNQ3 potassium channel activator
KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and...
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Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice
ObjectiveThe transient receptor potential vanilloid subtype 1 (TRPV1) channel is considered to play an important regulatory role in the process of...
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Comparison of K+ Channel Families
K+ channels enable potassium to flow across the membrane with great selectivity. There are four K+ channel families: voltage-gated K (Kv),...
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Biallelic CLCN2 mutations cause retinal degeneration by impairing retinal pigment epithelium phagocytosis and chloride channel function
CLCN2 encodes a two-pore homodimeric chloride channel protein (CLC-2) that is widely expressed in human tissues. The association between Clcn2 and...
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CNG channel structure, function, and gating: a tale of conformational flexibility
Cyclic nucleotide–gated (CNG) channels are key to the signal transduction machinery of certain sensory modalities both in vertebrate and invertebrate...
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Genomic Structure of Two Kv1.3 Channel Blockers from Scorpion Mesobuthus eupeus and Sea Anemone Stichodactyla haddoni and Construction of their Chimeric Peptide as a Novel Blocker
Different toxins acting on Kv1.3 channel have been isolated from animal venom. MeuKTX toxin from Mesobuthus eupeus phillipsi scorpion and shtx-k...
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A Design-assisted Spectrofluorometric Method Utilizing a One-pot Fluorescent Probe for the Quantitation of some Calcium Channel Blockers
Based on their reaction with highly fluorescent carbon quantum dots (CQDts), a precise and reliable spectrofluorometric approach was developed for...
