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Nociceptive Intra-epidermal Electric Stimulation Evokes Steady-State Responses in the Secondary Somatosensory Cortex
Recent studies have established the presence of nociceptive steady-state evoked potentials (SSEPs), generated in response to thermal or...
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Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation
Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep...
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Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials
Monitoring nociceptive processing is a current challenge due to a lack of objective measures. Recently, we developed a method for simultaneous...
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Targeting SHP2 for Cancer Treatment: Advances and Prospects
Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11, is a non-receptor protein tyrosine phosphatase that...
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Epigenetic regulation and factors that influence the effect of iPSCs-derived neural stem/progenitor cells (NS/PCs) in the treatment of spinal cord injury
Spinal cord injury (SCI) is a severe neurological disorder that causes neurological impairment and disability. Neural stem/progenitor cells (NS/PCs)...
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Methods of ex vivo analysis of tissue status in vascularized composite allografts
Vascularized composite allotransplantation can improve quality of life and restore functionality. However, the complex tissue composition of...
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Routes of Nano-drug Administration and Nano-based Drug Delivery System and Toxicity
In recent years, nanotechnology has grown significantly with enormous potential in technology in research and medicine to improve tissue engineering,...
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Novel effect of topical Roquinimex and its combination with Clobetasol on an imiquimod-induced model of psoriasis in mice
Psoriasis is a chronic inflammatory skin condition affecting multiple systems and the skin, with topical therapy representing the fundamental...
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pH-regulated single cell migration
Over the last two decades, extra- and intracellular pH have emerged as fundamental regulators of cell motility. Fundamental physiological and...
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Electrostimulable polymeric films with hyaluronic acid and lipid nanoparticles for simultaneous topical delivery of macromolecules and lipophilic drugs
This study focused on develo** electrically stimulable hyaluronic acid (HA) films incorporating lipid nanoparticles (NPs) designed for the topical...
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Advanced triboelectric nanogenerator-driven drug delivery systems for targeted therapies
In the current decade, remarkable efforts have been made to develop a self-regulated, on-demand and controlled release drug delivery system driven by...
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Pain-related evoked potentials with concentric surface electrodes in patients and healthy subjects: a systematic review
Pain-related evoked potentials with concentric surface electrodes (PREP with CE) have been increasingly used in the diagnostics of polyneuropathies...
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Versatile Hydrogels in Regenerative Medicine
Hydrogels, as the most typical polymer materials with three-dimensional network structures, have attracted wide attention owing to their outstanding...
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Patient-Derived Breast Cancer Tissue Cultures for Anti-Endocrine Drug Assays
BreastCancerBreast cancer is a complex and heterogeneous pathology, characterized by a variety of histological and molecular phenotypes. The majority...
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Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe side effect related to anticancer treatment, typically characterized by sensory...
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Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics
Microfluidics and biosensors have already demonstrated their potential in cancer research. Typical applications of microfluidic devices include the...
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Nanoparticles for Neural Applications
Nanotechnology represents a novel powerful technology with the potential to overcome some of the problems related to brain research. In particular,...
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Antibody-Based Biotherapeutics in Cancer
In this chapter, the different classes and characteristics of mAbs used as cancer therapeutics are described. Safety aspects of selected antibodies...
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Magnetic Field Parameters and Biological Sample Differences That Lead to Differential Bioeffects
We have to admit that the literature concerning bioeffects of electromagnetic fields is replete with reports that cannot be reproduced in other labs....
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Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opportunities and Limitations
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughtout the body. Classically, nAChRs were considered to mediate fast synaptic...