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Spinal Interneurons
This chapter deals with the neurons that constitute the majority of spinal neurons and are the main source of input to motoneurons, and therefore of...
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Revisiting the development of cerebellar inhibitory interneurons in the light of single-cell genetic analyses
The present review aims to provide a short update of our understanding of the inhibitory interneurons of the cerebellum. While these cells constitute...
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Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment
Aging is often associated with a decline in cognitive function. A reduction in the number of somatostatin-positive (SOM + ) interneurons in the dentate...
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Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells
BackgroundV0v spinal interneurons are highly conserved, glutamatergic, commissural neurons that function in locomotor circuits. We have previously...
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The plasticitome of cortical interneurons
Hebb postulated that, to store information in the brain, assemblies of excitatory neurons coding for a percept are bound together via associative...
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Specification and Development of GABAergic Interneurons
Of all cerebellar cells, the development of inhibitory interneurons is arguably least understood. The issue is further convoluted by the fact that...
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Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period
It is known that maternal immunoglobulins (Igs) are transferred to the offspring across the placenta. However, receiving maternal Igs, especially...
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Generation of Homogeneous Populations of Cortical Interneurons from Human Pluripotent Stem Cells
Cortical interneurons (cINs), especially those that are derived from the medial ganglionic eminence (MGE) during early development, are associated...
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Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy
Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic temporal lobe epilepsy (TLE), and interneuron grafting...
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Cortical VIP+ Interneurons in the Upper and Deeper Layers Are Transcriptionally Distinct
Different interneuron classes have distinct laminar distribution patterns which contribute to the layer-specific organization of cortical...
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Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury
Severe spinal cord injury in adults leads to irreversible paralysis below the lesion. However, adult rodents that received a complete thoracic lesion...
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mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory. Bidirectional modulation of somatostatin cell mTORC1...
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Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is characterized by difficulty in social behavior and restricted behaviors....
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Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties
To understand how the cerebellar cortex transforms mossy fiber (MF) inputs into Purkinje cell (PC) outputs, it is vital to delineate the elements of...
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Spinal Interneurons
This chapter deals with the neurons that constitute the majority of spinal neurons and are the main source of input to motoneurons, and therefore of...
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A spiking computational model for striatal cholinergic interneurons
Cholinergic interneurons in the striatum, also known as tonically active interneurons or TANs, are thought to have a strong effect on corticostriatal...
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Cortical interneurons in autism
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlap** set of...
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A Critical Role for γCaMKII in Decoding NMDA Signaling to Regulate AMPA Receptors in Putative Inhibitory Interneurons
CaMKII is essential for long-term potentiation (LTP), a process in which synaptic strength is increased following the acquisition of information....
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Genesis and Migration of Cerebral Cortical Inhibitory Interneurons: An Overview
The complexity of the cerebral cortex underlies human’s exceptional ability for organized thought and complex decision-making and problem-solving....
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Genesis and Migration of Cerebral Cortical Inhibitory Interneurons: An Overview
The complexity of the cerebral cortex underlies human’s exceptional ability for organized thought and complex decision-making and problem-solving....