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Aquaporin Inhibitors
Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles in various physiological progress including cell...
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Virus Entry Inhibitors Stop** the Enemy at the Gate
This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance...
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CDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors
BackgroundThe combined use of CDK4/6 inhibitors and mTOR inhibitors has achieved some clinical success in ccRCC. Exploring the underlying mechanism...
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Natural Products as Enzyme Inhibitors An Industrial Perspective
This book provides an overview of the latest developments and future challenges in enzyme inhibitor research. It discusses the general enzyme...
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Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
BackgroundInhibition of mutant KRAS challenged cancer research for decades. Recently, allele-specific inhibitors were approved for the treatment of KRAS-G12C...
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CDK4/6 inhibitors, PI3K/mTOR inhibitors, and HDAC inhibitors as second-line treatments for hormone receptor-positive, HER2-negative advanced breast cancer: a network meta-analysis
BackgroundThis study sought to compare the benefits and safety of agents including Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, phosphoinositide...
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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors
BackgroundTriple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors...
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Engineering New Protease Inhibitors Using α2-Macroglobulin
Protease inhibitors of the alpha-macroglobulin family (αM) have a unique mechanism that allows them to trap proteases that is dependent not on the...
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Novel CDK Inhibitors in Breast Cancer
Breast cancer is thought to be the most frequent kind of cancer in women globally. It is crucial to comprehend the biology of this tumor before...
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Immune Checkpoint Inhibitors in Urological Cancers
Over-expression of the immune checkpoint inhibitors is an important approach for malignant cells to escape the host immune system; therefore, the use...
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CTLA-4 Inhibitors for the Treatment of Lung Cancer
One of the most prevalent malignancies and the main reason for cancer-related deaths globally is lung cancer. The majority of these non-small-cell...
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BET Bromodomain Inhibitors as an Emerging Class of Anticancer Agents
Deregulated gene expression including epigenetic modulation is considered one of the most prominent factors that leads to tumorigenesis, thus...
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IDO and TGF-β Inhibitors for the Treatment of Lung Cancer
Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catalyzes the conversion of tryptophan to N-formylkynurenine, and it is the rate-limiting step in...
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Coronavirus Entry Inhibitors
Coronaviruses (CoVs) are enveloped RNA viruses that widely exist in the environment. Several CoVs possess a strong ability to infect humans, termed...
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Flavivirus Entry Inhibitors
Flaviviruses, including Dengue virus, Zika virus, Yellow fever virus, Japanese encephalitis virus, West Nile virus, cause thousands of deaths and...
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Computational Modeling of MAO Inhibitors as Anti-Alzheimer Agents
The incidence of neuropsychiatric diseases like Alzheimer’s disease (AD), depression, Parkinson’s disease (PD), etc. has increased rapidly, imposing...