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T Cell Subsets and Immune Homeostasis
T cells are a heterogeneous group of cells that can be classified into different subtypes according to different classification methods. The body’s...
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Immune Cell Ion Channels as Therapeutic Targets
The immune systemImmune systems and its components represent the body’s defensive apparatus against microbes, toxins, trauma, and neoplasms....
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Immune Homeostasis Methods and Protocols
This volume discusses different aspects of immune homeostasis regulation and its dysregulation during various diseases, including infections,...
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Flow Cytometry Analysis of Immune Cell Responses
Flow cytometry is a fluorescence-based technology that allows for the identification and characterization of immune cell subsets within a...
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Immune cell patterns before and after neoadjuvant immune checkpoint blockade combined with chemoradiotherapy in locally advanced esophageal squamous cell carcinoma
BackgroundNeoadjuvant immune checkpoint blockade (ICB) combined with chemoradiotherapy offers high pathologic complete response (pCR) rate for...
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Conserved stromal–immune cell circuits secure B cell homeostasis and function
B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance...
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Resha** the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers, especially those...
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Immune Cell Metabolism and Function
Immune cells are highly dynamic by nature and rely on metabolism to adapt to different conditions. Many recent studies have shown the importance of...
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Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases
By binding to multiple antigens simultaneously, multispecific antibodies are expected to substantially improve both the activity and long-term...
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Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
BackgroundDespite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of...
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New immune cell engagers for cancer immunotherapy
There have been major advances in the immunotherapy of cancer in recent years, including the development of T cell engagers — antibodies engineered...
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Immune cell phenotypes and mortality in the Framingham Heart Study
BackgroundGlobal life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable...
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Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes
BackgroundType 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic...
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Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability
In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body’s own cells. Develo** a precise understanding of the cell...
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The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients
Objective and designChanges in the immune status of patients with sepsis may have a major impact on their prognosis. Our research focused on changes...
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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Immune checkpoint inhibitor (ICI) therapy has revolutionized oncology, but treatments are limited by immune-related adverse events, including...
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Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies
Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as...
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TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator...
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Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological symptoms in pigs and humans,...
