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Phase-shifted tACS can modulate cortical alpha waves in human subjects
In the present study, we investigated traveling waves induced by transcranial alternating current stimulation in the alpha frequency band of healthy...
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A Phase I, Open-Label, Mass Balance Study of [14C]-Iberdomide in Healthy Subjects
BackgroundIberdomide is a novel potent cereblon modulator (CELMoD ® ) agent, which is currently under clinical development for hematological...
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Regulatory, Ethical and Political Challenges of Experimentation with LSD on Human Subjects
The inventor of LSD, Albert Hoffmann, himself referred to his most famous discovery as his ‘problem child’. In the first part of this chapter, we...
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Observation of Aerosol Generation by Human Subjects During Cardiopulmonary Exercise Testing Using a High-Powered Laser Technique: A Pilot Project
PurposeHuman respiratory aerosols may have important implications for transmission of pathogens. The study of aerosol production during vigorous...
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Reducing Events of Noncompliance in Neurology Human Subjects Research: the Effect of Human Subjects Research Protection Training and Site Initiation Visits
In an effort to minimize protocol noncompliance in neurological research studies that can potentially compromise patient safety, delay completion of...
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CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease
BackgroundEfavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-specific enzyme that metabolizes cholesterol to...
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Isolation and Differentiation of Neurons and Glial Cells from Olfactory Epithelium in Living Subjects
The study of psychiatric and neurological diseases requires the substrate in which the disorders occur, that is, the nervous tissue. Currently,...
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The speed of adaptation is dependent on the load type during target reaching by intact human subjects
When lifting or moving a novel object, humans are routinely able to quickly characterize the nature of the unknown load and swiftly achieve the...
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[1-11C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects
BackgroundReduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive...
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Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects
BackgroundGrowing evidence has demonstrated that DNA methylation (DNAm) plays an important role in Alzheimer’s disease (AD) and that DNAm differences...
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Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects
PurposeTo evaluate the clinical feasibility and tolerability of large volume subcutaneous delivery at different injection depths for lean and...
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Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease
BackgroundThis study investigated plasma biomarkers for neuroinflammation associated with Alzheimer’s disease (AD) in subjects with preclinical AD...
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Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis
Individuals with prodromal symptoms of Lewy body disease (LBD), such as rapid eye movement sleep behavior disorder (RBD), often showed imaging...
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Comparison of pharmacokinetics and safety of albuvirtide in healthy subjects after intravenous drip and bolus injection
Albuvirtide (ABT) is the first long-acting HIV fusion inhibitor developed in China, blocking the invasion of HIV-1 virus into target cells. This...
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On the Correlations of Gray Matter with Schizotypy in Mentally Healthy Subjects
We analyzed the relationships between morphometric characteristics of brain gray matter and schizotypy. Mentally healthy subjects ( n =164, age 18-35...
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Physiological Support of Goal-Directed Activity in Human
The effectiveness of goal-directed human behavior and the processes underlying organization of such activity are the subjects of various biomedical...
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Evaluation of serum miRNAs expression in frail and robust subjects undergoing multicomponent exercise protocol (VIVIFRAIL)
BackgroundFrailty, defined as physical performance impairment, is a common condition in older adults and can anticipate the development of...
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ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics
Abstract PurposeAlzeCure Pharma AB is develo** novel positive allosteric modulators of Trk-receptors for treatment of Alzheimer’s disease,...
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Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial
BackgroundAdministration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and...
