Search
Search Results
-
Gene expression associated with human brain activations in facial expression recognition
Previous studies identified some genetic loci of emotion, but few focused on human emotion-related gene expression. In this study, the facial...
-
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to...
-
Map** ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations
The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets respiratory cells,...
-
Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model
Neuronal gene expression in the brain dynamically responds to synaptic activity. The interplay among synaptic activity, gene expression, and synaptic...
-
Integrated analysis of robust sex-biased gene signatures in human brain
BackgroundSexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the...
-
Sex-biased gene and microRNA expression in the develo** mouse brain is associated with neurodevelopmental functions and neurological phenotypes
BackgroundSex differences pose a challenge and an opportunity in biomedical research. Understanding how sex chromosomes and hormones affect...
-
Population-level variation in enhancer expression identifies disease mechanisms in the human brain
Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding population-level variation...
-
Cytochromes P450 2F and Genes of Behavioral Traits: Covariations of Expression in the Human Brain and Polymorphism of the Orthologs in Domestic Goats
AbstractHuman cytochrome P450 2F1, as well as its ortholog 2F3 in domestic goat, is considered to be a rather unusual enzyme. The only type of...
-
Engineered compact pan-neuronal promoter from Alphaherpesvirus LAP2 enhances target gene expression in the mouse brain and reduces tropism in the liver
Small promoters capable of driving potent neuron-restricted gene expression are required to support successful brain circuitry and clinical gene...
-
Multiomic profiling of transcription factor binding and function in human brain
Transcription factors (TFs) orchestrate gene expression programs crucial for brain function, but we lack detailed information about TF binding in...
-
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular...
-
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders....
-
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease
BackgroundMicroglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes...
-
-
Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain
BackgroundOur understanding of the molecular underpinnings of chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem...
-
Expression patterns of AEG-1 in the normal brain
Astrocyte elevated gene-1 ( AEG -1) is a well-known oncogene implicated in various types of human cancers, including brain tumors. Recently, AEG-1 has...
-
Expression profile of the proapoptotic protein Bax in the human brain
Bax is a well-known universal proapoptotic protein. Bax protein is detected in almost all human organs, and its expression levels can be correlated...
-
Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying mechanisms. Here, we investigated the influence of...
-
GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells
The organization of mammalian genomes features a complex, multiscale three-dimensional (3D) architecture, whose functional significance remains...
-
Effects of a novel probiotic mixture on the modulation of brain and intestine Aquaporin-4 gene expression in rats exposed to Cadmium
Cadmium (Cd) is a toxicant metal that risks human and animal health. Nowadays, the vital role of Aquaporin-4 (AQP-4) in brain and gut cell...
