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Analysis of the Guanine Nucleotide-Bound State of KRAS by Ion-Pair Reversed-Phase High-Performance Liquid Chromatography
Guanine nucleotides can be quantitatively analyzed by high-performance liquid chromatography (HPLC). Here we describe an ion-pair reversed-phase HPLC... -
Rapid Analysis of Estrogens in Meat Samples by High Performance Liquid Chromatography with Fluorescence Detection
A novel reagent named 4-(N-methyl-1,3-dioxo-benzoisoquinolin-6-yl-oxy)benzene sulfonyl chloride (MBIOBS-Cl) for the determination of estrogens in...
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Falsified and problematic methandienone products available online: active pharmaceutical ingredient identification by portable Raman spectrometers and quantification by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry
This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic...
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Ultra-performance liquid chromatography coupled with quadrupole high-resolution time-of-flight mass spectrometry for metabolite profiling and biological activity of Stellaria pallida (Dumort) Piré
Medicinal plants have a wide variety of valuable biological activities. Stellaria pallida (Dumort) Piré is a well-known plant; however, this species’...
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Clinical evaluation of an authorized medical equipment based on high performance liquid chromatography for measurement of serum voriconazole concentration
BackgroundTherapeutic drug monitoring for voriconazole is recommended for its optimum pharmacotherapy. Although the feedback of the measurement...
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High-Performance Liquid Chromatography Map** Method for the Structural Analysis of N-Glycans at the Molecular, Cellular, and Tissue Levels
Glycans on viruses are major molecules that mediate the communication of the viruses with host cells. Investigating the structure of glycans may be... -
Determination of Neonicotinoid Insecticides in Bee Products by Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
As a result of growing concern regarding the disappearance of pollinators, numerous studies have been carried out in different countries in an... -
High Performance Liquid Chromatography
High performance liquid chromatography (HPLC) is a form of liquid chromatography which is used to separate the individual components of interest... -
Investigation of an Uncommon Artifact during Reducing Capillary Electrophoresis-Sodium Dodecyl Sulfate Analysis of a Monoclonal Antibody with Dynamic Light Scattering and Reversed Phase High-Performance Liquid Chromatography
PurposesIn reducing capillary electrophoresis sodium dodecyl sulfate (CE-SDS) analysis of a monoclonal antibody (mAb-1), the peak area ratio of heavy...
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Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
Special populations, like geriatric patients, experience altered paracetamol pharmacokinetics (PK), complicating pain management. More PK research is...
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Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)
Nicotinamide adenine dinucleotide (NAD + ) is an essential metabolite for fundamental biological phenomena, including aging. Nicotinamide...
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Analysis of Silicone Oil in Prefilled Syringes and Biopharmaceutical Drug Products Using High-Performance Liquid Chromatography
As the packaging of choice for many therapeutic proteins, prefilled syringes have been widely used in biopharmaceutical industry as primary...
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Liquid Chromatography Tandem Mass Spectrometric Method for Quantification of Margetuximab in Rat Plasma and Application to a Pharmacokinetic Study
Margetuximab was approved for the treatment of advanced HER2+ breast cancer. A feasible analytical technique that can measure this drug was...
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Liquid Chromatography-Mass Spectrometry Analysis of Peripheral Blood Mononuclear Cells from SARS-CoV-2 Infected Patients
COVID-19 disease is caused by infection with the SARS-CoV-2 virus and is associated with a cytokine storm effect in some patients. This can lead to... -
Gel Filtration Chromatography
Apart from finding multitudes of applications in chemical, medicinal, and pharmaceutical research, gel filtration chromatography (GFC) has also... -
Sensitive and Stereospecific High-Performance Liquid Chromatographic Method for Flurbiprofen in Human Plasma
Flurbiprofen (FLU), a chiral 2-arylpropionic acid (2-APA) nonsteroidal anti-inflammatory drug (NSAID), is used in its racemic form. Enantiomers are... -
Method Development and Validation of Gallic Acid in Liquid Dosage Form by Using RP-HPLC Method
A simple, rapid, precise, sensitive, and reproducible reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed for... -
Mitochondrial Coenzyme Q10 Determination Via Isotope Dilution Liquid Chromatography –Tandem Mass Spectrometry
Coenzyme Q10 (CoQ10) Coenzyme Q10 (CoQ10) is an essential part of the mitochondrial respiratory chainRespiratory chains . Here, we describe an... -
Importance of Chromatography Techniques in Phytomedicine Research
Chromatography is a technique including thin-layer chromatography, column chromatography, high-performance liquid chromatography, and gas-liquid... -
Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma
BackgroundThe utility of O 6 -methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with...