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Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants,...
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Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants,...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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On the Disbalance and Impairment of Serotonin Heteroreceptor Complexes in the Rat Brain After MDMA and Hallucinogens Administration
The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the CNS gives a new...
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Susceptibility of GPCR Heteroreceptor Complexes to Neurotoxins. Relevance for Neurodegenerative and Psychiatric Disorders
G protein-coupled receptors (GPCRs) possess significant patterns of intrinsic unfolding. GPCRs have similarities to proteins that have a high net...
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Susceptibility of GPCR Heteroreceptor Complexes to Neurotoxins. Relevance for Neurodegenerative and Psychiatric Disorders
G protein-coupled receptors (GPCRs) possess significant patterns of intrinsic unfolding. GPCRs have similarities to proteins that have a high net...
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Study of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay
Membrane receptor, for example, G-protein-coupled receptors (GPCRs), operates via coordinated changes between the receptor expression, their...
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The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson’s Disease
The adenosine A 2A receptor (A 2A R), dopamine D 2 receptor (D 2 R) and metabotropic glutamate receptor type 5 (mGluR 5 ) form A 2A R-D 2 R-mGluR 5 heteroreceptor...
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OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes
Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if...
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D1R-5-HT2AR Uncoupling Reduces Depressive Behaviours via HDAC Signalling
Dopamine and serotonin signalling are associated with major depressive disorder, which is a prevalent life-threatening illness worldwide. Numerous...
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Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways
ARA 290, an 11-amino acid linear nonhematopoietic peptide derived from the three-dimensional structure of helix B of the erythropoietin (EPO),...
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Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates
Endocannabinoids are neuromodulators acting on specific cannabinoid CB 1 and CB 2 G-protein-coupled receptors (GPCRs), representing potential...
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Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes
The current study was performed to establish the actions of nanomolar concentrations of cocaine, not blocking the dopamine transporter, on dopamine...
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Adenosinergic Pathway in Parkinson’s Disease: Recent Advances and Therapeutic Perspective
Parkinson’s disease (PD) is a neurodegenerative disease characterized pathologically by α-synuclein (α-syn) aggregation. In PD, the current mainstay...
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Changes in Targets as an Explanation for Drug Resistance in Epilepsy
Drug resistance in epilepsy is a condition that limits the control of seizure activity. The drug target hypothesis postulates changes in those...
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Isolation and Detection of G Protein-Coupled Receptor (GPCR) Heteroreceptor Complexes in Rat Brain Synaptosomal Preparation Using a Combined Brain Subcellular Fractionation/Co-immunoprecipitation (Co-IP) Procedures
The isolation and characterization of GPCR heteroreceptor complexes, specially those present at the central nervous system, are of crucial relevance...
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Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats
Antagonistic allosteric A2AR-D2R receptor-receptor interactions in heteroreceptor complexes counteract cocaine self-administration and cocaine...
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The role of serotonin neurotransmission in rapid antidepressant actions
RationaleKetamine has rapid antidepressant effects that represent a significant advance in treating depression, but its poor safety and tolerability...
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Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions
BackgroundSpatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are...
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Novel Interactions Involving the Mas Receptor Show Potential of the Renin–Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia
The renin–angiotensin system (RAS) not only plays an important role in controlling blood pressure but also participates in almost every process to...
