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Changes in Targets as an Explanation for Drug Resistance in Epilepsy

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Pharmacoresistance in Epilepsy

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Abstract

Drug resistance in epilepsy is a condition that limits the control of seizure activity. The drug target hypothesis postulates changes in those targets on which antiseizure medications act. Alterations in drug targets can be structural or localization in nature and signal transduction changes. This chapter describes changes in targets associated with drug resistance in epilepsy. In addition, other mechanisms are suggested by which target availability or signaling might be compromised, contributing to the pharmacoresistant phenotype of epilepsy.

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Acknowledgments

We thank the National Council for Science and Technology (CONACyT) for the scholarships (753802, CMA; 489736, DFB; and 1009939, MFM) and grant A3-S-26782.

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Authors and Affiliations

  1. Pharmacobiology Department, Center for Research and Advanced Studies, México, Mexico

    Christopher Martínez-Aguirre, Daniel Fonseca-Barriendos, Monserrat Fuentes-Mejia & Luisa L. Rocha

  2. Pharmacology Department, University of Vermont, Burlington, VT, USA

    Saúl Huerta de la Cruz

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  1. Christopher Martínez-Aguirre
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  4. Monserrat Fuentes-Mejia
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Correspondence to Luisa L. Rocha .

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  1. Pharmacobiology Department, Center for Research and Advanced Studies, México, Mexico

    Luisa L. Rocha

  2. Institute for Research in Physiopathology and Clinical Biochemistry (INFIBIOC), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

    Alberto Lazarowski

  3. Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil

    Esper A. Cavalheiro

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Martínez-Aguirre, C., Fonseca-Barriendos, D., Huerta de la Cruz, S., Fuentes-Mejia, M., Rocha, L.L. (2023). Changes in Targets as an Explanation for Drug Resistance in Epilepsy. In: Rocha, L.L., Lazarowski, A., Cavalheiro, E.A. (eds) Pharmacoresistance in Epilepsy. Springer, Cham. https://doi.org/10.1007/978-3-031-36526-3_7

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