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The significant mechanism and treatments of cell death in heatstroke
With global warming, extreme environmental heat is becoming a social issue of concern, which can cause adverse health results including heatstroke...
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CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury
The intestine is one of the main target organs involved in the pathological process of heatstroke. CCAAT/enhancer-binding protein homologous protein...
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Inflammation, coagulation, and cellular injury in heat-induced shock
BackgroundThe number of heatstroke victims hit record numbers in 2022 as global warming continues. In heat-induced injuries, circulatory shock is the...
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Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage
Heatstroke (HS) is an acute clinical disease characterized by abnormal hyperthermia and multi-organ dysfunction. Heme oxygenase (HO)-1, also called...
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Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats
This study aimed to elucidate the neurotherapeutic effect of hyperbaric oxygen (HBO) on brain injury and the potential role of dynamin-related...
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Loss of disability-adjusted life years due to heat-related sleep disturbance in the Japanese
The purpose of this study was to quantify the sleep disturbances caused by climate change using disability-adjusted life years (DALY). The revised...
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Impacts of previous heatstroke history on physiological parameters eHSP72 and biomarkers of oxidative stress in military working dogs
Heatstroke (HS) is an acute, progressive life-threatening emergency. Animals, including military working dogs (IDFMWD), rapidly activate...
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Regulatory T Cells Could Improve Intestinal Barrier Dysfunction in Heatstroke
Intestinal barrier dysfunction plays a pivotal role in multiorgan dysfunction during heatstroke (HS). Neutrophils are involved in intestinal...
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Evolution of MRI characteristics of heatstroke in a patient with schizophrenia maintained with antipsychotic drugs
Although heatstroke commonly occurs in summer, herein, we present a case of heatstroke that occurred in March. The patient has been schizophrenic for...
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Malaria and Climate Change
Climate change is a global phenomenon which has affected virtually everything biotic and abiotic on earth. In context with public health the...
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Procalcitonin expression in patients with large cell neuroendocrine carcinoma of the lung
ObjectiveProcalcitonin (PCT) has received much attention as a serum marker for bacterial infection. Elevated serum PCT is occasionally seen in severe...
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Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis
PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis, and is implicated in organ injury and mortality in...
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Triptolide induces PANoptosis in macrophages and causes organ injury in mice
Macrophages represent the first lines of innate defense against pathogenic infections and are poised to undergo multiple forms of regulated cell...
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Hard Boiled: Alcohol Use as a Risk Factor for MDMA-Induced Hyperthermia: a Systematic Review
Although MDMA (ecstasy) is a relatively safe recreational drug and is currently considered for therapeutic use for the treatment of posttraumatic...
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NLRP3 ablation enhances tolerance in heat stroke pathology by inhibiting IL-1β-mediated neuroinflammation
BackgroundPatients with prior illness are more vulnerable to heat stroke-induced injury, but the underlying mechanism is unknown. Recent studies...
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The History of Thermal Physiology in Israel
This chapter will cover the historical development of thermoregulatory studies in Israel since the establishment of The Hebrew University of...
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Hazards in Pharmaceutical Industry
Pharmaceutical unit operations follow standard operating procedures (SOPs); however, there are still chances of multiple hazards that may occur...
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Serum histones as biomarkers of the severity of heatstroke in dogs
Heatstroke is associated with systemic inflammatory response syndrome, leading to multiple organ dysfunction and death. Currently, there is no...
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Analysis of heat stroke and heat exhaustion cases in EudraVigilance pharmacovigilance database
BackgroundThe frequency and intensity of heat waves have increased and will keep increasing. This meteorological phenomenon, which is considered one...
