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Composite CYP3A (CYP3A4 and CYP3A5) phenotypes and influence on tacrolimus dose adjusted concentrations in adult heart transplant recipients
CYP3A5 genetic variants are associated with tacrolimus metabolism. Controversy remains on whether CYP3A4 increased [* 1B (rs2740574), * 1 G ...
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Dose-Dependent Heart Rhythm Disturbance Occurring in Response to the Activation of Choline-Reactive Structures in Early Rat Ontogeny
The effect of dose-dependent activation of cholinoreactive structures on the severity of sinus bradycardia occurring in some intact newborn rats...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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Sacubitril/valsartan compared to equivalent/sub-equivalent dose angiotensin receptor blocker or angiotensin-converting enzyme inhibitor in heart failure with reduced ejection fraction: a meta-analysis of randomized trials
PurposeThe objective of this meta-analysis is to determine how sacubitril/valsartan (SV) compares to equivalent and sub-equivalent angiotensin...
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Maximum Tolerated Dose (MTD) Studies in Drug Toxicology Assessments
In order to transition a new chemical entity (NCE) from the discovery arena into nonclinical development and potentially the clinic, a comprehensive...
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Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats
Epilepsy is a chronic neurological disease that affects more than 50 million people worldwide. Antiepileptic drugs (AEDs) are the mainstay of...
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Dose Range Finding (DRF) Studies in Drug Toxicology Assessments
Early repeated dose-range finding (DRF) toxicology studies, usually conducted in rodent and non-rodent animal species, seek to provide the earliest...
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Dose delivery reproducibility for PBS proton treatment of breast cancer patients with and without mask immobilization
BackgroundSetup reproducibility of the tissue in the proton beam path is critical in maintaining the planned clinical target volume (CTV) dose...
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A retrospective study of adjuvant proton radiotherapy for breast cancer after lumpectomy: a comparison of conventional-dose and hypofractionated dose
PurposeThis study aimed to compare the adverse reactions of conventional-dose and hypofractionated dose of proton therapy for breast cancer.
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Association of effective dose to immune cells and vertebral marrow dose with hematologic toxicity during neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma
BackgroundTo explore the correlation between effective dose to immune cells (EDIC) and vertebral bone marrow dose and hematologic toxicity (HT) for...
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Quantitative analysis of the impact of respiratory state on the heartbeat-induced movements of the heart and its substructures
PurposeThis study seeks to examine the influence of the heartbeat on the position, volume, and shape of the heart and its substructures during...
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Palliative Care for People Living with Heart Failure
Heart failure (HF) is a clinical syndrome affecting approximately 5 million people worldwide, causing a significant symptom burden and reducing both...
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Daily dose evaluation based on corrected CBCTs for breast cancer patients: accuracy of dose and complication risk assessment
ObjectivesThe goal of this study is to validate different CBCT correction methods to select the superior method that can be used for dose evaluation...
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Recent successes in heart failure treatment
Remarkable recent advances have revolutionized the field of heart failure. Survival has improved among individuals with heart failure and a reduced...
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Δ9-Tetrahydrocannabinol Effects on Respiration and Heart Rate Across Route of Administration in Female and Male Mice
The physiological impact of cannabinoid receptor agonists is of great public health interest due to their increased use in recreational and...
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Evaluation of risk due to chronic low dose ionizing radiation exposure on the birth prevalence of congenital heart diseases (CHD) among the newborns from high-level natural radiation areas of Kerala coast, India
BackgroundThe human population residing in monazite bearing Kerala coast are exposed to chronic low dose and low dose rate external gamma radiation...
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Comparison of different dose accumulation strategies to estimate organ doses after stereotactic magnetic resonance-guided adaptive radiotherapy
IntroductionRe-irradiation is frequently performed in the era of precision oncology, but previous doses to organs-at-risk (OAR) must be assessed to...
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LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration
Leucine-rich repeat containing 10 (LRRC10) is a cardiomyocyte-specific protein, but its role in cardiac biology is little understood. Recently Lrrc10...
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Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies
BackgroundNo population-based cohort study investigated a potential inverse association between long-term low-dose acetylsalicylic acid (ASA) use and...
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A randomized phase II study of full dose gemcitabine versus reduced dose gemcitabine and nab-paclitaxel in vulnerable patients with non-resectable pancreatic cancer (DPCG-01)
BackgroundAccording to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy,...
