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Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers
BackgroundEMLA cream is a local anesthetic. The pharmacokinetics and dermal effects of a topical anesthetic formulation has not been evaluated in...
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Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers
PurposeCurrently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight...
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The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers
BackgroundThe emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds,...
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Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers
Background and ObjectiveAlthough polypharmacy is a particular challenge in daily rheumatological practice, clinical research on the effects of...
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The effects of virtual reality environmental enrichments on craving to food in healthy volunteers
RationaleEnvironmental enrichment (EE) is a non-pharmacological approach that has been shown to be effective in reducing food-taking in rats. Studies...
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Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers
Background and ObjectiveAstaxanthin is a naturally occurring carotenoid with high anti-oxidant properties, but it is a very lipophilic compound with...
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Survey the change of skin surface temperature at the face when using tonifying or dispersing acupuncture manipulations at dazhui acupoint in healthy volunteers
In addition to stimulating specific acupoints, acupuncture uses manipulations with varying effects. For Dazhui acupoint, tonifying acupuncture clears...
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Perception of clinical research among patients and healthy volunteers of clinical trials
PurposeClinical research relies on data from patients and volunteers, yet the target sample size is often not achieved. Here, we assessed the...
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Autonomic and Behavioral Indicators on Increased Cognitive Loading in Healthy Volunteers
Cognitive and emotional loading during increases in task difficulty leads to activation of various parts of the autonomic nervous system and can be...
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Pharmacokinetics, Safety Profile, and Tolerability of Tetramethylpyrazine Nitrone Tablets After Single and Multiple Ascending Doses in Healthy Chinese Volunteers
Background and ObjectivesTetramethylpyrazine nitrone (TBN) is a novel tetramethylpyrazine derivative armed with a strong free radical scavenging...
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Cerebellar Asymmetry of Motivational Direction: Anger-Dependent Effects of Cerebellar Transcranial Direct Current Stimulation on Aggression in Healthy Volunteers
It has recently been theorized that the frontal asymmetry of approach- and avoidance-related motivation is mirrored in the posterolateral cerebellum....
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Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers
PurposeA population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing...
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Evaluation of drug interactions of saxagliptin with sildenafil in healthy volunteers
PurposeThe purpose of this study is to investigate the effect of sildenafil a CYP3A4 substrate and inhibitor on the pharmacokinetics and safety of...
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Electronic Cigarette Va** with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
Electronic cigarette (EC) va** is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC...
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Cerebellar Grey Matter Volumes in Reactive Aggression and Impulsivity in Healthy Volunteers
Several lines of evidence point towards the involvement of the cerebellum in reactive aggression. In addition to the posterior cerebellar hemisphere,...
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Perturbation and resilience of the gut microbiome up to 3 months after β-lactams exposure in healthy volunteers suggest an important role of microbial β-lactamases
BackgroundAntibiotics notoriously perturb the gut microbiota. We treated healthy volunteers either with cefotaxime or ceftriaxone for 3 days, and...
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Pharmacokinetics of chloroquine and primaquine in healthy volunteers
BackgroundVivax malaria is a neglected disease. There is an irrefutable need for better treatments with higher acceptability and efficacy. The...
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Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers
Background and objectiveDefinity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as...
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Pharmacokinetics and bioequivalence evaluation of 2 oral formulations of methotrexate tablets in healthy Chinese volunteers under fasting and fed conditions
Methotrexate is an anti-metabolite drug that is frequently used for rheumatoid arthritis treatment. This study is aimed at evaluating the...
