Search
Search Results
-
Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer
Thyroid cancer is a prevalent endocrine malignancy with increasing incidence in recent years. Although most thyroid cancers grow slowly, they can...
-
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
Sex differences are present across multiple non-reproductive organ cancers, with male individuals generally experiencing higher incidence of cancer...
-
Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts...
-
Hallmarks of Cancer: Molecular Underpinnings
Cancer, a genetic disease, is an autonomous organ composed of heterogeneous cancer cell clones supported by its microenvironment. The cancer cells...
-
Oncogenes, Signal Transduction and the Hallmarks of Cancer
In this chapter, we will understand that the observation that RNA tumor viruses can transform normal cells into cancer cells led to the discovery of...
-
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults
Age-related declines in immune response pose a challenge in combating diseases later in life. Influenza (flu) infection remains a significant burden...
-
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to...
-
Hallmarks of Cancer: Its Concept and Critique
The complicated chronobiology of carcinogenesis has been organized by concept of cancer hallmarks. Though this concept has already mapped out the...
-
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
BackgroundMutations in the β-glucocerebrosidase ( GBA1 ) gene do cause the lysosomal storage Gaucher disease (GD) and are among the most frequent...
-
The New Dimension of the Renin-Angiotensin System in the Hallmarks of Cancer
The renin angiotensin-system, its well-known systemic regulation of the systemic pressure and its role in hypertension has been widely studies, but...
-
Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective
Epigenetic regulation of gene expression is a fundamental determinant of molecular and cellular function, and epigenetic reprogramming in the context...
-
Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients...
-
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach
Severe dengue (SD) is a major cause of morbidity and mortality. To define dengue virus (DENV) target cells and immunological hallmarks of SD...
-
Hallmarks of T cell aging
The aged adaptive immune system is characterized by progressive dysfunction as well as increased autoimmunity. This decline is responsible for...
-
Protein post-translational modifications in the regulation of cancer hallmarks
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety...
-
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by variable cognitive impairment, immune dysregulation,...
-
PBX1: a key character of the hallmarks of cancer
Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a fusion protein resulting from the chromosomal...
-
RNA splicing dysregulation and the hallmarks of cancer
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types. Cancer-associated splicing alterations arise from both...
-
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer’s disease (AD) and is characterised by systemic changes in both intracellular and extracellular...
-
The Critical Role of RNA m6A Methylation in Gliomas: Targeting the Hallmarks of Cancer
Gliomas are the most common central cancer with high aggressive-capacity and poor prognosis, remaining to be the threat of most patients. With the...
