Search
Search Results
-
Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (ICCA) is a heterogeneous group of malignant tumors characterized by high recurrence rate and poor...
-
Genome folding principles uncovered in condensin-depleted mitotic chromosomes
During mitosis, condensin activity is thought to interfere with interphase chromatin structures. To investigate genome folding principles in the...
-
Mechanism of phase condensation for chromosome architecture and function
Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this...
-
Physiology and pharmacological targeting of phase separation
Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment...
-
Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer
BackgroundDysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of G9a in tumorigenesis and...
-
The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells
BackgroundIntrahepatic cholangiocarcinoma (ICC), originating from the bile ducts, is the second most common primary liver malignancy, and its...
-
Hijacking of transcriptional condensates by endogenous retroviruses
Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality...
-
Interaction between non-coding RNAs, mRNAs and G-quadruplexes
G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of...
-
Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells
Pericentromeric heterochromatin is mostly composed of repeated DNA sequences, which are prone to aberrant recombination during double-strand break...
-
Liquid–liquid phase separation drives cellular function and dysfunction in cancer
Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical pathways that have escaped the regulatory bounds of normal...
-
HIRA vs. DAXX: the two axes sha** the histone H3.3 landscape
H3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression...
-
DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau
Alzheimer’s disease (AD) is the most prevalent form of neurodegeneration. Despite the well-established link between tau aggregation and clinical...
-
Histone Chaperones in Cancer
Histone epigenetics has three layers including histone modifications, histone variants, and histone chaperones. Unlike the first two components,...
-
Histone Chaperones in Cancer
Histone epigenetics has three layers including histone modifications, histone variants, and histone chaperones. Unlike the first two components,...
-
Overview of Histone Modification
Epigenetics is the epi-information beyond the DNA sequence that can be inherited from parents to offspring. From years of studies, people have found...
-
Cellular senescence in cancer: clinical detection and prognostic implications
Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. Historically, it has been...
-
The interactions between PML nuclear bodies and small and medium size DNA viruses
Promyelocytic leukemia nuclear bodies (PM NBs), often referred to as membraneless organelles, are dynamic macromolecular protein complexes composed...
-
Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of mammalian genomic sequence. TEs are capable of making additional...
-
Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
BackgroundIndividuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism...
