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Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection
Although previous studies have suggested that subtype B HIV-1 proviruses in the brain are associated with physiological changes and immune activation...
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Cerebrospinal fluid CD14++CD16+ monocytes in HIV-1 subtype C compared with subtype B
CD14 ++ CD16 + monocytes are susceptible to HIV-1 infection, and cross the blood–brain barrier. HIV-1 subtype C (HIV-1C) shows reduced Tat protein...
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Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C
IntroductionHIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir...
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Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG
The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria...
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Impact of subtype C-specific amino acid variants on HIV-1 Tat-TAR interaction: insights from molecular modelling and dynamics
BackgroundHIV-1 produces Tat, a crucial protein for transcription, viral replication, and CNS neurotoxicity. Tat interacts with TAR, enhancing HIV...
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HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
BackgroundNef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction...
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HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response, and neuronal apoptosis
NOTCH receptors are relevant to multiple neurodegenerative diseases. However, the roles and mechanisms of NOTCH receptors in HIV-associated...
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Systematic post-mortem analysis of brain tissue from an HIV-1 subtype C viremic decedent revealed a paucity of infection and pathology
Whether the human brain is a robust reservoir for HIV-1 subtype C has yet to be established. We aimed to determine whether HIV-1 subtype C infection...
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HIV-1 subtype C Tat exon-1 amino acid residue 24K is a signature for neurocognitive impairment
Variation and differential selection pressures on Tat genes have been shown to alter the biological function of the protein, resulting in...
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Construction and Characterization of HIV-1 env-Pseudoviruses of the Recombinant Form CRF63_02A and Subtype A6
HIV-1 env -pseudoviruses are a useful tool in the search for antiviral drugs (entry inhibitors) and evaluation of the efficacy of HIV-1 vaccines....
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Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis
BackgroundEthiopia is among the highly HIV-affected countries, with reported 12,000 and 12,000 AIDS-related deaths and incidents as per reports from...
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Molecular epidemiology of the HIV-1 epidemic in Fiji
Very little is known about the HIV-1 epidemic in Fiji, nor the wider South Pacific region more generally, yet new reported HIV-1 infections are on...
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HIV-1 Vif protein sequence variations in South African people living with HIV and their influence on Vif-APOBEC3G interaction
PurposeDespite extensive research, HIV-1 remains a global epidemic with variations in pathogenesis across regions and subtypes. The Viral Infectivity...
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Characterization of an imported HIV-1 A1/A7/G recombinant in China
BackgroundInternational migration has accelerated the HIV-1 spread across national borders, gradually reducing the restrictions on the geographical...
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Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy
Mosaic HIV-1 vaccines have been shown to elicit robust humoral and cellular immune responses in people living with HIV-1 (PLWH), that had started...
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A longitudinal analysis of immune escapes from HLA-B*13-restricted T-cell responses at early stage of CRF01_AE subtype HIV-1 infection and implications for vaccine design
BackgroundIdentifying immunogens which can elicit effective T cell responses against human immunodeficiency virus type 1 (HIV-1) is important for...
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A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
BackgroundMaturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1)....
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Sex differences in cognitive function among people with HIV-1 clade C infection in Northern India
Human immunodeficiency virus-1 (HIV-1) clade C is the most prevalent form of HIV-1 comprising nearly 46% of global infections and is the dominant...
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Recombinant characteristics of three novel HIV-1 second-generation recombinant forms composed of CRF01_AE and CRF07_BC isolated in Hebei province, China
Human immunodeficiency virus 1 (HIV-1) is a fast-evolving, genetically diverse virus. The HIV-1 evolution rate is also significantly influenced by...
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Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
BackgroundOur understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1...
