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ZC3H13 Accelerates Keloid Formation by Mediating N6-methyladenosine Modification of HIPK2
Keloids are fibroproliferative skin disorders caused by the improper healing of wounded skin. A growing body of evidence suggests the involvement of...
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Sevoflurane-Induced Neurotoxicity in the Develo** Hippocampus via HIPK2/AKT/mTOR Signaling
Sevoflurane (Sev) is a widely used inhalational anesthetic for general anesthesia in children. Previous studies have confirmed that multiple...
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Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy
BackgroundHomeodomain-interacting protein kinase 2 ( HIPK2 ) has increasingly drawn attention as recent researches demonstrated its unique role in the...
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METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner
Breast cancer (BC) is the most prevalent malignant neoplasm among women and is the fifth most common cause of cancer-associated death worldwide....
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Gene expression analysis reveals diabetes-related gene signatures
BackgroundDiabetes is a spectrum of metabolic diseases affecting millions of people worldwide. The loss of pancreatic β-cell mass by either...
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Identification of ZBTB4 as an immunological biomarker that can inhibit the proliferation and invasion of pancreatic cancer
BackgroundZinc finger and BTB domain-containing protein 4 (ZBTB4) belongs to the zinc finger protein family, which has a role in regulating...
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The role of m6A methylation in therapy resistance in cancer
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of...
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Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study
BackgroundThe prevalence of type 2 diabetes has dramatically increased in the past years. Increasing evidence supports that blood DNA methylation,...
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Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such...
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FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat...
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Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program
BackgroundBronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by...
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Encounter with the Unknown
The severe respiratory syndrome human coronavirus 2 (SARS-CoV-2) pandemic has forced us to recognize the need for rapid analysis of unknown viral...
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Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner
Silencing of the Apoptosis associated Tyrosine Kinase gene ( AATK ) has been described in cancer. In our study, we specifically investigated the...
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N-Methyl-D-Aspartate Receptor Signaling-Protein Kinases Crosstalk in Cerebral Ischemia
Although stroke is very often the cause of death worldwide, the burden of ischemic and hemorrhagic stroke varies between regions and over time...
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DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are...
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Do Carcinogens Have a Threshold Dose? The Pros and Cons
With sound understanding of biological concepts, the notion of threshold effect levels has grown in acceptance especially for electrophile-induced...
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Do Carcinogens Have a Threshold Dose? The Pros and Cons
With sound understanding of biological concepts, the notion of threshold effect levels has grown in acceptance especially for electrophile-induced...
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Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer
BackgroundStudies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. Our...
