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The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus
Nonalcoholic fatty liver disease (NAFLD), more appropriately known as metabolic (dysfunction) associated fatty liver disease (MAFLD), a prevalent...
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The gut-liver axis in hepatobiliary diseases
Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases....
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Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
The close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) provides a good opportunity to comprehend...
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Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles
BackgroundThe application of titanium dioxide nanoparticles (TiO 2 NPs) as food additives poses a risk of oral exposure that may lead to adverse...
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The potential liver injury induced by metronidazole-provoked disturbance of gut microbiota: modulatory effect of turmeric supplementation
It has been reported that the gut-liver axis and intestinal microbiome contribute crucially to different liver diseases. So, targeting this...
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Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study
BackgroundEpidemiological studies have indicated a potential link between the gut microbiome and autoimmune liver disease (AILD) such as autoimmune...
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Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis
BackgroundBile acids can regulate liver disease progression by affecting the functions of gut microbiota and immune cells. As the most potent natural...
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Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota
The pharmacology of urolithin C (UroC) on non-alcoholic fatty liver disease (NAFLD) is largely undetermined. We sought to investigate the potential...
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Mulberry branch fiber improved lipid metabolism and egg yolk fatty acid composition of laying hens via the enterohepatic axis
BackgroundThe utilization of mulberry branch fiber (MF), the largest by-product of the sericulture industry, is an important issue. Supplementation...
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Gut microbiome, liver immunology, and liver diseases
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology. The liver is a central...
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Gut-Derived Exosomes Induce Liver Injury After Intestinal Ischemia/Reperfusion by Promoting Hepatic Macrophage Polarization
Liver injury induced by intestinal ischemia/reperfusion (I/R) is accompanied by the polarization of Kupffer cells, which are specialized macrophages...
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Gut Microbiome and Liver Cancer
Liver cancer is a major cause of cancer-related death, and its incidence keeps rising. The liver is exposed to gut microbial products and metabolites...
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Coadministration of metformin prevents olanzapine-induced metabolic dysfunction and regulates the gut-liver axis in rats
ObjectiveOlanzapine is widely prescribed for patients with mental disorders; however, it may induce metabolic dysfunction. Metformin is an efficient...
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Sialic acid exacerbates gut dysbiosis-associated mastitis through the microbiota-gut-mammary axis by fueling gut microbiota disruption
BackgroundMastitis is one of the most severe diseases in humans and animals, especially on dairy farms. Mounting evidence indicates that...
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CCL5/CCR5 Axis in Cancer
Inflammatory chemokines were primarily thought of in the past as essential "gatekeepers" of immunity and inflammation. Recent findings suggest that...
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Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes
BackgroundClinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D)...
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The Microbiota-Gut-Liver Axis: Implications for the Pathophysiology of Liver Disease
Interactions between the gut and the liver in relation to immunological responses and metabolic functions have been recognized as central to...
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Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects
A significant rise in metabolic disorders, frequently brought on by lifestyle choices, is alarming. A wide range of preliminary studies indicates the...
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The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease
Imbalance between fat production and consumption causes various metabolic disorders. Nonalcoholic fatty liver disease (NAFLD), one such pathology, is...
