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Evaluating the utility of multi-gene, multi-disease population-based panel testing accounting for uncertainty in penetrance estimates
Panel germline testing allows for the efficient detection of deleterious variants for multiple conditions, but the benefits and harms of identifying...
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Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?
BackgroundThere is no consensus regarding the specific genes included in the homologous recombination repair (HRR) gene panel for identifying the HRR...
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Network analysis identifies a gene biomarker panel for sepsis-induced acute respiratory distress syndrome
BackgroundAcute respiratory distress syndrome (ARDS) is characterized by non-cardiogenic pulmonary edema caused by inflammation, which can lead to...
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Clinical impact of panel gene sequencing on therapy of advanced cancers of the digestive system: a retrospective, single center study
BackgroundPanel gene sequencing is an established diagnostic tool for precision oncology of solid tumors, but its utility for the treatment of...
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Inflammatory Gene Panel Guiding the Study of Genetics in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a complex disease that develops through a sequence of molecular events that are still poorly defined. This...
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Genome sequencing with gene panel-based analysis for rare inherited conditions in a publicly funded healthcare system: implications for future testing
NHS genetics centres in Scotland sought to investigate the Genomics England 100,000 Genomes Project diagnostic utility to evaluate genome sequencing...
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Predicting tumor repopulation through the gene panel derived from radiation resistant colorectal cancer cells
BackgroundTumor cells with the capability of radiation resistance can escape the fate of cell death after radiotherapy, serving as the main cause of...
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Gene Panel Sequencing Analysis Revealed a Strong Contribution of Rare Coding Variants to the Risk of Parkinson’s Disease in Sporadic Moroccan Patients
Parkinson’s disease (PD) is a neurodegenerative movement disorder which can be either familial or sporadic. While it is well known that monogenic...
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Psychological and health behaviour outcomes following multi-gene panel testing for hereditary breast and ovarian cancer risk: a mini-review of the literature
IntroductionKnowledge of the genetic mechanisms driving hereditary breast and ovarian cancer (HBOC) has recently expanded due to advances in gene...
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Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing
Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing are urgently required. Most...
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Custom gene expression panel for evaluation of potential molecular markers in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. It is a highly heterogeneous disease with...
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Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer
BackgroundThis study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of...
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Panel of Candidate Genes to Predict the Survival of Patients with Clear Cell Renal Cancer on the Basis of Gene Expression Regulated by HIF1α/HIF2α
The detection of genes related to the lifetime of patients with clear cell renal cancer provides information on the mechanisms of the tumor...
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Selection criteria for assembling a pediatric cancer predisposition syndrome gene panel
Increasing use of genomic sequencing enables standardized screening of all childhood cancer predisposition syndromes (CPS) in children with cancer....
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Analysis of genetic variants in myeloproliferative neoplasms using a 22-gene next-generation sequencing panel
BackgroundThe Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs), namely essential thrombocythaemia (ET), polycythaemia vera (PV) and...
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HOXA9 gene promotor methylation and copy number variation of SOX2 and HV2 genes in cell free DNA: A potential diagnostic panel for non-small cell lung cancer
BackgroundMost cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a...
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A complete chromosome substitution map** panel reveals genome-wide epistasis in Arabidopsis
Chromosome substitution lines (CSLs) are tentatively supreme resources to investigate non-allelic genetic interactions. However, the difficulty of...
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Quality Control of an Isogenic H/N/KRAS-Less Mouse Embryonic Fibroblast Cell Line Panel
Isogenic H/N/KRAS-less mouse embryonic fibroblast (MEF) cell lines have been developed to assist in cell-based assays of RAS inhibitors. The quality...
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Integrated approach to functional analysis of an ERBB2 variant of unknown significance detected by a cancer gene panel test
PurposeDealing with variants of unknown significance (VUS) is an important issue in the clinical application of NGS-based cancer gene panel tests. We...
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A proteomic classifier panel for early screening of colorectal cancer: a case control study
BackgroundDiagnosis of colorectal cancer (CRC) during early stages can greatly improve patient outcome. Although technical advances in the field of...
