Search
Search Results
-
Death-associated protein 3 in cell death and beyond
Death-associated protein 3 (DAP3) is a highly conserved guanosine triphosphate (GTP) binding protein. As a component of the mitochondrial ribosome...
-
FLIM-FRET Protein-Protein Interaction Assay
Fluorescence lifetime imaging performed under FRET conditions between two interacting molecules is a sensitive and robust way to quantify...
-
-
Proteases and Protein Kinases as Potential Drug Target
Recently, the successful pharmacological targeting of protein and phosphoinositide kinases has been applied to a wide range of diseases, most notably...
-
Protein Kinase A in neurological disorders
Cyclic adenosine 3’, 5’ monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide...
-
The stress-responsive protein REDD1 and its pathophysiological functions
Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including...
-
Targeting protein interaction networks in mitochondrial dynamics for neurodegenerative diseases
Mitochondria, the powerhouse of eukaryotic cells, are the central organelle controlling energy metabolism and apoptosis. Based on metabolic needs,...
-
RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP
BackgroundRas gene mutation and/or overexpression are drivers in the progression of cancers, including colorectal cancer. Blocking the Ras signaling...
-
Profiling Complex RAS-Effector Interactions Using NMR Spectroscopy
Knowledge of how effectors interact with RAS GTPases is key to understanding how these switch-like proteins function in cells. Effectors bind...
-
Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice
BackgroundAutophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family,...
-
Expansion of the neurodevelopmental phenotype of individuals with EEF1A2 variants and genotype-phenotype study
Translation elongation factor eEF1A2 constitutes the alpha subunit of the elongation factor-1 complex, responsible for the enzymatic binding of...
-
Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth
BackgroundAlthough molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully...
-
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is regulated by over 40 enzymes, targeting more than...
-
-
Structure Composition and Intracellular Transport of Clathrin-Mediated Intestinal Transmembrane Tight Junction Protein
Tight junctions (TJs) are located in the apical region of the junctions between epithelial cells and are widely found in organs such as the brain,...
-
GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear...
-
Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition
BackgroundCingulin (CGN) is a pivotal cytoskeletal adaptor protein located at tight junctions. This study investigates the link between CGN mutation...
-
PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy
Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited....
-
The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β
Endothelial cell (EC) barrier disruption and inflammation are the pathological hallmarks of vascular disorders and acute infectious diseases and...
-
Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly and represents a major clinical challenge in the ageing society....
