Search
Search Results
-
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells
Apoptosis plays an important role in both carcinogenesis and cancer treatment. Understanding the mechanisms through which resistance to apoptosis...
-
Genetic, serological and clinical evaluation of childhood myasthenia syndromes- single center subgroup analysis experience in Turkey
BackgroundCongenital myasthenic syndrome is a disease that occurs due to several types such as mutations in different pre-synaptic, synaptic,...
-
GFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer
Our previous studies revealed a novel link between gemcitabine (GEM) chemotherapy and elevated glutamine-fructose-6-phosphate transaminase 2 (GFPT2)...
-
Neurological Consequences of Congenital Disorders of Glycosylation
The chapter is devoted to neurological aspects of congenital disorders of glycosylation (CDG)Congenital disorders of glycosylation (CDG). At the...
-
Exome sequencing in undiagnosed congenital myopathy reveals new genes and refines genes–phenotypes correlations
BackgroundCongenital myopathies are severe genetic diseases with a strong impact on patient autonomy and often on survival. A large number of...
-
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration
Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. We utilized a larval tail regeneration assay...
-
Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2
BackgroundOncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to...
-
Assessing the Association of the Degree of DNA Methylation and the Frequency of Chromosomal Aberrations in Human Lymphocytes in a Single Irradiation of Blood In Vitro
AbstractThe most sensitive biomolecule under radiation exposure is DNA, whose damage manifests itself in the form of chromosomal aberrations (CA)....
-
Next-generation sequencing profiling of miRNAs in individuals with 22q11.2 deletion syndrome revealed altered expression of miR-185-5p
BackgroundThe 22q11.2 deletion syndrome (22q11.2DS) is a microdeletion syndrome with highly variable phenotypic manifestations, even though most...
-
Prognostic relevance of the hexosamine biosynthesis pathway activation in leiomyosarcoma
Metabolic reprogramming of tumor cells and the increase of glucose uptake is one of the hallmarks of cancer. In order to identify metabolic pathways...
-
Weighted burden analysis of rare coding variants in 470,000 exome-sequenced UK Biobank participants characterises effects on hyperlipidaemia risk
A previous study of 200,000 exome-sequenced UK Biobank participants investigating the association between rare coding variants and hyperlipidaemia...
-
A Role for Fructose Metabolism in Development of Sheep and Pig Conceptuses
The period of conceptus (embryo and extraembryonic membrane) development between fertilization and implantation in mammalian species is critical as...
-
Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research
Zebrafish is a powerful platform in the modern era of phenotype-based drug discovery and eminent vertebrate model to study disease progression and...
-
Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity
BackgroundMicroglia play a pivotal role in neuroinflammation, while obesity triggers hypothalamic microglia activation and inflammation. Sirt6 is an...
-
A proteomic analysis of Bcl-2 regulation of cell cycle arrest: insight into the mechanisms
B cell lymphoma 2 ( Bcl-2 ) is an important antiapoptotic gene that plays a dual role in the maintenance of the dynamic balance between the survival...
-
Identification and functional analysis of a three-miRNA ceRNA network in hypertrophic scars
BackgroundHypertrophic scar (HTS) is a fibrotic disorder of skins and may have repercussions on the appearance as well as functions of patients....
-
A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification
BackgroundPulmonary hypertension (PH), an infrequent disease, is characterized by excessive pulmonary vascular remodeling and proliferation of...
-
Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer metabolism, more than 70 years since Sidney Farber introduced...
