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Overview of the Development of the Human Brain and Spinal Cord
The development of the human brain and spinal cord may be divided into several phases, each of which is characterized by particular developmental...
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The Placenta as a Neuroendocrine Organ
Pregnancy is a unique situation, in which two (or more) individuals are in intimate contact, with development of the foetus supported by a...
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Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses
Prenatal alcohol exposure is a major cause of neurobehavioral disabilities. MRI studies in humans have shown that alcohol is associated with white...
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Transient Polycomb activity represses developmental genes in growing oocytes
BackgroundNon-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic...
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Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment...
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Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
BackgroundPrenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and is associated with...
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Prepubertal nutritional modulation in the bull and its impact on sperm DNA methylation
Enhanced pre-pubertal nutrition in Holstein bulls increased reproductive hormone production and sperm production potential with no negative effects...
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Increased PLAGL1 Gene Methylation in Cord Blood is Positively Correlated with Brain Injury in Chorioamniotic Preterm Infants
The study aims to explore the epigenetic mechanisms of neurodevelopmental impairment accompanied in chorioamniotic preterm infants. Our study...
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Applying the adverse outcome pathway concept for assessing non-monotonic dose responses: biphasic effect of bis(2-ethylhexyl) phthalate (DEHP) on testosterone levels
Male reproduction is one of the primary health endpoints identified in rodent studies for some phthalates, such as DEHP (Bis(2-ethylhexyl)...
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Unravelling the Parkinson’s puzzle, from medications and surgery to stem cells and genes: a comprehensive review of current and future management strategies
Parkinson's disease (PD) is a neurodegenerative disorder, prevalent in the elderly population. Neuropathological hallmarks of PD include loss of...
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Genomics and justice: mitigating the potential harms and inequities that arise from the implementation of genomics in medicine
Advances in human genetics raise many social and ethical issues. The application of genomic technologies to healthcare has raised many questions at...
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Phytoconstituents for Boosting the Stem Cells Used in Regenerative Medicine
Purpose of ReviewStem cells are the group of undifferentiated or partially differentiated cells which have the potential to distinguish in various...
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Stress-Sensitive Regulators of Fetal Neurodevelopment in HIV and Preeclampsia: An Immunocytochemical Appraisal of Placental OGT and T4 Levels
Preeclampsia and HIV are a significant burden to maternal health globally, especially in low-middle income countries such as South Africa. In the...
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Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors
Precisely sensing and guiding cell-state transitions via the conditional genetic activation of appropriate differentiation factors is challenging....
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In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
BackgroundEpigenomic dysregulation has been linked to solid tumour malignancies, including ovarian cancers. Profiling of re-programmed enhancer...
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iPSCs and their Role in Amelioration of Neurodegenerative Disorders
Since the birth of human-induced pluripotent stem cells (iPSCs) in 2007, its applications have been widened to solve the challenges of metabolic and...
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Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the ability to modify host responses to disease-relevant...
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PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis
BackgroundLeptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological...
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The macrophage: a key player in the pathophysiology of peripheral neuropathies
Macrophages are present in all mammalian tissues and coexist with various cell types in order to respond to different environmental cues. However,...
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Cerebellar Developmental Disorders and Cerebellar Nuclei
While significant progress has been made in the last 10 years in understanding the development of cerebellar nuclei, they remain a relatively less...