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Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium...
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Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes
Hemiplegic migraine (HM) is a rare subtype of migraine with aura. Given that causal missense mutations in the voltage-gated calcium channel α1A...
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Astrocytic Glutamate Transporters and Migraine
Glutamate levels and lifetime in the brain extracellular space are dinamically regulated by a family of Na + - and K + -dependent glutamate transporters,...
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Migraine
Migraine is a common, disabling disorder in the central nervous system. Migraine is a disorder that has three key features: the tendency is largely...
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The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function
CACNA1A pathogenic variants have been linked to several neurological disorders including familial hemiplegic migraine and cerebellar conditions. More...
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Oxidative Stress and Migraine
The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, according to data from an...
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The NMDA receptor antagonists memantine and ketamine as anti-migraine agents
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors:...
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Current Update on Categorization of Migraine Subtypes on the Basis of Genetic Variation: a Systematic Review
Migraine is a complex neurovascular disorder that is characterized by severe behavioral, sensory, visual, and/or auditory symptoms. It has been...
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Role of Omics in Migraine Research and Management: A Narrative Review
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to...
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Glia Signaling and Brain Microenvironment in Migraine
Migraine is a complicated neurological disorder affecting 6% of men and 18% of women worldwide. Various mechanisms, including neuroinflammation,...
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Glutamate in Migraine Neurobiology and Treatment
Migraine is a disabling chronic condition characterised by recurrent episodes of head pain accompanied by other sensory disturbances. Its...
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Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association...
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Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies
Epilepsy and migraine are both episodic disorders and share clinical as well as pathophysiological mechanisms. The prevalence of epilepsy in migraine...
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Progressive Ataxia with Hemiplegic Migraines: a Phenotype of CACNA1A Missense Mutations, Not CAG Repeat Expansions
We report a 52-year-old woman presenting with autosomal dominant progressive cerebellar ataxia and familial hemiplegic migraine type 1 whose genetic...
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Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation — a Therapeutic Perspective in Migraine?
Persistent reprogramming of epigenetic pattern leads to changes in gene expression observed in many neurological disorders. Transient receptor...
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Integrating eQTL and GWAS data characterises established and identifies novel migraine risk loci
Migraine—a painful, throbbing headache disorder—is the most common complex brain disorder, yet its molecular mechanisms remain unclear. Genome-wide...
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Botulinum Toxin Treatment in Migraine and Other Headaches
Prospective, double-blind and placebo-controlled studies (PREEMPT) have demonstrated the efficacy of onabotulinumtoxinA (onaA) in chronic migraine...
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A review of migraine genetics: gathering genomic and transcriptomic factors
Migraine is a common and complex neurologic disorder that affects approximately 15–18% of the general population. Although the cause of migraine is...
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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide...
