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Mucosal Exposome and Intestinal Carcinogenesis
Mucosal exposomes are the internal frontline of defense against xenobiotics, pathogens, and microbiota. The mucosal network of human immunity is...
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Exposome on skeletal muscle system: a mini-review
Exposomics is an ever-expanding field which captures the cumulative exposures to chemical, biological, physical, lifestyle, and social factors...
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Assessing the contribution of the chemical exposome to neurodegenerative disease
Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and...
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The Role of the Neural Exposome as a Novel Strategy to Identify and Mitigate Health Inequities in Alzheimer’s Disease and Related Dementias
With the continuous increase of the elderly population, there is an urgency to understand and develop relevant treatments for Alzheimer’s disease and...
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A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases
Age-related diseases account for almost half of all diseases among adults worldwide, and their incidence is substantially affected by the exposome,...
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Applying an Exposome-wide Association Study (ExWAS) Approach to Latino Cancer Disparities
Latinos have higher incidence rates of cervical, gall bladder, liver, and gastric cancer, and higher mortality rates for six cancer sites than US...
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The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
The “totality” of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related...
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Minimally Invasive Biospecimen Collection for Exposome Research in Children’s Health
Purpose of ReviewThe advent of low-volume biosampling and novel biomarker matrices offers non- or minimally invasive approaches to sampling in...
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Unraveling phenotypic variance in metabolic syndrome through multi-omics
Complex multi-omics effects drive the clustering of cardiometabolic risk factors, underscoring the imperative to comprehend how individual and...
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Proteogenomic insights into early-onset endometrioid endometrial carcinoma: predictors for fertility-sparing therapy response
Endometrial carcinoma remains a public health concern with a growing incidence, particularly in younger women. Preserving fertility is a crucial...
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Understanding exposomes and its relation with cancer risk in Malaysia based on epidemiological evidence: a narrative review
The prevalence of cancer is increasing globally, and Malaysia is no exception. The exposome represents a paradigm shift in cancer research,...
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Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to environmental exposures and pollutants. An appreciation of...
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Extracellular Vesicles: Footprints of environmental exposures in the aging process?
Purpose of the reviewExtracellular vesicles (EVs) are nano-sized lipid particles that participate in intercellular signaling through the trafficking...
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Nutrigenomics: A Broader Concept
Nutrigenomics is one aspect of the interaction between environment and genes. The term exceeds the conventional understanding of the genes affecting...
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Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort
BackgroundThe human exposome is composed of diverse metabolites and small chemical compounds originated from endogenous and exogenous sources,...
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Impacts of Environmental Insults on Cardiovascular Aging
Purpose of ReviewWith cardiovascular disease (CVD) being the top cause of deaths worldwide, it is important to ensure healthy cardiovascular aging...
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Addressing Breast Cancer Disparities in Advancements for Conquering Drug Resistance
Breast cancer is a global concern with high morbidity and mortality rates. While incidence rates remain high in developed countries compared to...
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Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study
Background:Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization...
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Use of Exposomic Methods Incorporating Sensors in Environmental Epidemiology
Purpose of ReviewThe exposome is a recently coined concept that comprises the totality of nongenetic factors that affect human health. It is...
