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Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology
The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals...
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Effects of Array Design on Acoustic Propagation Modeling in Seismic Surveys
Marine seismic surveys are large-scale tests used to study the seabed and sub-seabed by utilizing sound reflected from the ocean bottom, generated...
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Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents
Bispecific and multispecific agents have become increasingly utilized in cancer treatment and immunotherapy, yet their complex design parameters...
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An Experimental Design Approach for Development of Crocin-Loaded Microparticles Embedded in Gelatin/Oxidized Alginate-Based Hydrogel
PurposeThe objective of this study was to prepare gelatin/oxidized alginate (OAlg) hydrogel incorporating chitosan (CS)/alginate (Alg) microparticles...
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Effects of Various Interval Hypoxic Training Regimens in Experimental Models of Anxious-Depressive States in Rats
The development of non-drug-based methods for correcting stress-induced disorders and improving adaptation to stress remains an urgent task in...
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An Experimental Phototherapy Device for Studying the Effects of Blue Light on Patients with Raynaud’s Phenomenon
Raynaud’s phenomenon (RP) is a condition that causes decreased blood flow to areas perfused by small blood vessels (e.g., fingers, toes). In severe...
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Clinically Applicable Experimental Design and Considerations for Stroke Recovery Preclinical Studies
Development of stroke recovery therapies is an active field of research and represents an opportunity to reduce the global impact of stroke as the...
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Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization Using an Experimental Design
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra,...
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A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch
PurposeA two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the...
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Fundamentals of Design of Experiments and Optimization: Experimental Designs in Response Surface Methodology
Designing an experiment to fit a response surface model typically involves selecting a design among several candidates. There are often many...
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The effects of vitamin C on respiratory, allergic and immunological diseases: an experimental and clinical-based review
Vitamin C is used in modern medicine supplements for treatment of various disorders associated with oxidative stress, inflammation and immune...
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Limited training and transfer effects in older and young adults who participated in 12 sessions of process-based working memory training. A three-armed pretest-posttest design study
ObjectiveNumerous studies confirm the effectiveness of cognitive training in older adults. However, there is limited evidence of the transfer...
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Design, Analysis and Experimental Validation of a Novel 7-Degrees of Freedom Instrument for Laparoscopic Surgeries
Laparoscopic surgery is widely used for treating intra-abdominal conditions involving the gallbladder, pancreas, liver, intestines and reproductive...
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In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
The experimental myocardial infarction (MI) model originating from isoproterenol (ISO) is frequently preferred in research due to its similarity to...
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In Vitro and In Vivo Evaluation of Metformin Hydrochloride Hydrogels Developed with Experimental Design in the Treatment of Burns
Burns alter the normal skin barrier and affect various host defense processes that help prevent infections. An ineffective repair process can lead to...
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Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by...
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Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation
PurposeBepotastine besilate, a second-generation antihistamine commonly prescribed to treat allergic rhinitis and urticarial/pruritus, has a short...
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Capitalizing on skin in orthotics design: the effects of texture on plantar intrinsic foot muscles during locomotion
Foot orthoses (FO) are a commonly prescribed intervention to alter foot function during walking although their effects have been primarily studied in...
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A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
BackgroundMajor depressive disorder (MDD) represents a major public health concern, particularly due to its steadily rising prevalence and the poor...
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Bioactive Extract Production from Citrullus Clocynthis Fruit via Microwave-Assisted Extraction: Experimental Optimization, Process Design and Economics with Uncertainty Quantification
PurposeDespite a huge pharmacological and medicinal significance of Citrullus Colocynthis fruit (CCF) extract as claimed by previous researchers,...
