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Physical exercise for a healthy pregnancy: the role of placentokines and exerkines
Complications such as diabetes and preeclampsia can occur during pregnancy. Moderate-intensity exercise can prevent such complications by releasing...
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Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review
BackgroundExerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during and after physical exercise. Exerkines...
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Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease
BackgroundNeuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer’s disease...
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Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
The beneficial effects of exercise on the proper functioning of the body have been firmly established. Multi-systemic metabolic regulation of...
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Exercise and Diet in the Control of Inflammation and Pain
Lifestyle choices, such as exercise and diet, can play significant roles in mediating inflammation and consequently, pain. Functional medicine is an...
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Hepatic kynurenic acid mediates phosphorylation of Nogo-A in the medial prefrontal cortex to regulate chronic stress-induced anxiety-like behaviors in mice
Exercise training effectively relieves anxiety disorders via modulating specific brain networks. The role of post-translational modification of...
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Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions
The health benefits of exercise training in a cancer setting are increasingly acknowledged; however, the underlying molecular mechanisms remain...
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Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive cognitive decline and increase vulnerability to...
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The effect of physical exercise on anticancer immunity
Regular physical activity is associated with lower cancer incidence and mortality, as well as with a lower rate of tumour recurrence. The...
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Extracellular Vesicles: Footprints of environmental exposures in the aging process?
Purpose of the reviewExtracellular vesicles (EVs) are nano-sized lipid particles that participate in intercellular signaling through the trafficking...
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Endurance-dependent urinary extracellular vesicle signature: shape, metabolic miRNAs, and purine content distinguish triathletes from inactive people
Extracellular vesicles (EVs) enriched with bioactive molecules have gained considerable attention in nanotechnology because they are critical to...
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Exercise-derived skeletal myogenic exosomes as mediators of intercellular crosstalk: a major player in health, disease, and exercise
Exosomes are extracellular membrane vesicles that contain biological macromolecules such as RNAs and proteins. It plays an essential role in...
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Prospective Advances in Beneficial Effects of Exercise on Human Health
Physical inactivity increases the chance of many adverse health conditions. It has been well recognized that exercise exerts widespread beneficial...
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The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases
Currently, the most widespread global ailment is not COVID-19COVID-19 or any other such devastating infectious diseases. In fact, obesity has been...
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Exercise and Cardiovascular Protection
Accumulating evidence has demonstrated that exercise training not only reduces cardiovascular disease risk but also provides direct endogenous...
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Exosomal Secretion of Adipose Tissue during Various Physiological States
Exosomes are secreted extracellular vesicles containing a wide array of biologically active components. Recent studies have demonstrated that...
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Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks
Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the...
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Effects of MicroRNAs and Long Non-coding RNAs on Beneficial Action of Exercise on Cognition in Degenerative Diseases: A Review
Recent research has exposed a growing body of proof underscoring the importance of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in...
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Molecular and Cellular Aspects of Sarcopenia, Muscle Healthy Aging and Physical Conditioning in the Elderly
During aging, the skeletal muscle tissue is one of the most affected, undergoing loss of mass and function, a process defined as sarcopenia. This...
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Bodywide ecological interventions on cancer
Historically, cancer research and therapy have focused on malignant cells and their tumor microenvironment. However, the vascular, lymphatic and...
