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Locally administered nanosuspension increases delivery of estradiol for the treatment of vaginal atrophy in mice
Vaginal atrophy affects up to 57% of post-menopausal women, with symptoms ranging from vaginal burning to dysuria. Estradiol hormone replacement...
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Kinetic Characterization of Estradiol Glucuronidation by Liver Microsomes and Expressed UGT Enzymes: The Effects of Organic Solvents
Background and ObjectiveIn vitro glucuronidation of 17β-estradiol (estradiol) is often performed to assess the role of uridine...
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Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β-catenin in an estradiol withdrawal model
RationaleClinical and preclinical studies have demonstrated that estradiol withdrawal after delivery is one of important factors involved in the...
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Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle...
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Testosterone, β-estradiol, and hepatocellular carcinoma: stimulation or inhibition? A comparative effect analysis on cell cycle, apoptosis, and Wnt signaling of HepG2 cells
Unlike breast and prostate cancers, which are specifically affected by estrogens or androgens, hepatocellular carcinoma has been reported to be...
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PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes
AbstractPoly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity, and they were first described...
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Transdermal Delivery of Estradiol Simultaneously Possessing Rapid Release and Sustained Release Effect
Dissolving microneedle (DMN) has been researched as a drug delivery technology that improves drug molecule transportation through the skin with...
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Fasting for 48 h induced similar glucose intolerance in both sexes despite greater perceived stress and decreased estradiol levels in females
PurposeThe purpose of this study was to compare the effects of fasting for 48 h on the evoked insulin and glucose responses in males and females, and...
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RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
Production of estradiol (E2) by the placenta during human pregnancy ensures successful maintenance of placental development and fetal growth by...
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Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
RationaleThe female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal...
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The Bruce Effect: Complementary Roles of Olfactory Memory and Male-Sourced Estradiol
Uterine implantation of fertilized ova is a highly sensitive transition from minimal maternal investment to increasing devotion of resources to...
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Non-genomic Effect of Estradiol on the Neurovascular Unit and Possible Involvement in the Cerebral Vascular Accident
Cerebrovascular diseases, such as ischemic cerebral vascular accident (CVA), are responsible for causing high rates of morbidity, mortality, and...
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Modulatory effect of ciprofloxacin, a broad spectrum antibacterial drug, on mPT pore using rat model with estradiol benzoate–induced endometrial hyperplasia
Mitochondrial permeability transition (mPT) pore has become a motive for drug evolvement pertinent to dysregulated apoptosis situations. Some...
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Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
Background17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy...
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Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study
IntroductionMetformin may provide a therapeutic benefit in different types of malignancy.
PurposeWe aimed at evaluating the effect of metformin as...
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miR-223 Enhances the Neuroprotection of Estradiol Against Oxidative Stress Injury by Inhibiting the FOXO3/TXNIP Axis
Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder characterized by complex pathogenesis, of which oxidative stress has long been...
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An investigation of the potential effects of amitriptyline on polycystic ovary syndrome induced by estradiol valerate
Polycystic ovarian syndrome (PCOS) is frequently observed in adolescent women and usually progresses with depression. The aim of this study was to...
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Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives
As 17 β -estradiol and its derivatives have good affinity with estrogen receptors and have unique antitumor properties, O 1 -propargyl- N 4 , N 4 -bis(2-chloroe...
