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Viral remodeling of the 4D nucleome
The dynamic spatial organization of genomes across time, referred to as the four-dimensional nucleome (4DN), is a key component of gene regulation...
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4C Analysis of EBV-Host DNA Interactome
EBV persist as multicopy episomes in latently infected cells and alter transcriptional program of host systems. Knowledge of EBV tethering site helps...
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Structure and transcription of integrated HPV DNA in vulvar carcinomas
HPV infections are associated with a fraction of vulvar cancers. Through hybridization capture and DNA sequencing, HPV DNA was detected in five of...
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Association between oncogenic human papillomavirus type 16 and Killian polyp
BackgroundKillian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to...
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Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers
Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated...
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Oncolytic Viruses and Viral Gene Therapy Vectors: Principles of Safety
With the emergence of genetic engineering, a new era of viral safety was introduced. Apart from the means to attenuate classical viral vaccines, new...
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AAV Serotypes and Their Suitability for Retinal Gene Therapy
Throughout the last 25 years, exceptional progress in retinal gene therapy was achieved. The major breakthrough was realized in 2017 when the FDA...
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Ewing sarcoma treatment: a gene therapy approach
Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes...
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Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells
BackgroundKaposi’s sarcoma-associated herpesvirus (KSHV) is a transforming gammaherpesvirus. Like other herpesviruses, KSHV infection is for life...
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Reactivation of varicella zoster virus following trigeminal schwannoma resection
Varicella zoster is found exclusively in humans. Infected people with this virus result in chickenpox followed by dormant virus within neural...
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Complete genome sequence analysis, morphology and structural protein identification of two Bacillus subtilis phages, BSTP4 and BSTP6, which may form a new species in the genus Salasvirus
In the present study, two new Bacillus subtilis phages, BSTP4 and BSTP6, were isolated and studied further. Morphologically, BSTP4 and BSTP6 are...
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The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy
Extrachromosomal DNA (ecDNA) amplification has been observed in at least 30 different cancer types and is associated with worse patient outcomes....
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Navigating therapeutic strategies: HPV classification in head and neck cancer
The World Health Organisation recognised human papillomavirus (HPV) as the cause of multiple cancers, including head and neck cancers. HPV is a...
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Designer nucleases to treat malignant cancers driven by viral oncogenes
Viral oncogenic transformation of healthy cells into a malignant state is a well-established phenomenon but took decades from the discovery of...
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Let it glow: genetically encoded fluorescent reporters in Plasmodium
The use of fluorescent proteins (FPs) in Plasmodium parasites has been key to understand the biology of this obligate intracellular protozoon. FPs...
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Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer
Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to...
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Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that...
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Small ring has big potential: insights into extrachromosomal DNA in cancer
Recent technical advances have led to the discovery of novel functions of extrachromosomal DNA (ecDNA) in multiple cancer types. Studies have...
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Oncogenic Virus-Induced Oxidative Stress and Epigenetic Regulation: An Insight into Host DNA Methylation
Stress response pathways alter the pathophysiological state of an organism that can culminate into oxidative stress by accumulation of reactive...
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Oncogenic Virus-Induced Oxidative Stress and Epigenetic Regulation: An Insight into Host DNA Methylation
Stress response pathways alter the pathophysiological state of an organism that can culminate into oxidative stress by accumulation of reactive...