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Epileptogenesis in Posttraumatic Epilepsy
Posttraumatic epilepsy (PTE) is a severe, disabling, delayed consequence of a traumatic brain injury. The mechanism by which trauma to the brain...
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The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy
Epilepsy is a multifaceted neurological syndrome characterized by recurrent, spontaneous, and synchronous seizures. The pathogenesis of epilepsy,...
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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the...
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The role of molecular chaperones in the mechanisms of epileptogenesis
Epilepsy is a group of neurological diseases which requires significant economic costs for the treatment and care of patients. The central point of...
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Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Epilepsy is a chronic and debilitating neurological disorder, known for the occurrence of spontaneous and recurrent seizures. Despite the...
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Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
BackgroundThe astrocytes in the central nervous system (CNS) exhibit morphological and functional diversity in brain region-specific pattern....
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The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Epileptic seizures are frequently referred to as a brief development of a number of signs and symptoms resulting from extreme or synchronized...
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Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis
Increasing evidence corroborates the fundamental role of neuroinflammation in the development of epilepsy. Proinflammatory cytokines (PICs) are...
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TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis
Increasing evidence suggests that inflammation promotes epileptogenesis. TAK1 is a central enzyme in the upstream pathway of NF-κB and is known to...
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Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
There is an unmet need to develop alternative therapeutic strategies to not only restrain seizures but also to alleviate the underlying pathologies...
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The Role or NMDA Receptors in Epileptogenesis
Epilepsy is characterized by repeated sudden-onset epileptic seizures. Around 30% of cases of epilepsy show drug resistance, with the result that the...
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11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice
BackgroundGlucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving...
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The Structural Basis of Epileptogenesis in an Adult Patient: Experience of Complex Diagnosis
Diagnosis of the structural basis of focal epilepsy in an adult patient was used as an example for considering the potential of the multimodal and...
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Novel Approaches to Prevent Epileptogenesis After Traumatic Brain Injury
Traumatic brain injury (TBI) is defined as an alteration in brain function or other evidence of brain pathology caused by an external force. When...
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PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability
Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ...
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Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis
IntroductionMitochondrial dysfunction is a common denominator of neuroinflammation recognized by neuronal oxidative stress-mediated apoptosis that is...
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Role of Mutations of Mitochondrial Aminoacyl-tRNA Synthetases Genes on Epileptogenesis
Mitochondria are the structures in cells that are responsible for producing energy. They contain a specific translation unit for synthesizing...
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The functions of repressor element 1-silencing transcription factor in models of epileptogenesis and post-ischemia
Epilepsy is a debilitating neurological disorder characterised by recurrent seizures for which 30% of patients are refractory to current treatments....
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Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogenesis
Brain injury is one of the common causes of acquired epilepsy. Current treatments include anti-epileptic drugs that are anticonvulsant. However,...
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Functional Genomics of Epileptogenesis in Animal Models and Humans
It has been estimated that epilepsies are among the top five neurological diseases with the highest burden of disease. In recent years, genome-wide...
