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Neuroprotection by Kynurenine Metabolites
The overexcitation of excitatory amino acid receptors generates excitotoxicity, which plays an important role in the pathophysiology of various...
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Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan
Humans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human...
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Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones
Alzheimer's disease (AD) is a central nervous system disease that can lead to cognitive impairment and progressive memory loss. An increasing number...
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Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites
Hemorrhagic transformation (HT) is a common serious complication of stroke after thrombolysis treatment, which limits the clinical use of tissue...
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Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction
Dementia, as an advanced diabetes-associated cognitive dysfunction (DACD), has become the second leading cause of death among diabetes patients....
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The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation
Izencitinib is a novel, orally administered pan-JAK inhibitor designed as a gut-selective therapy that was under development for the treatment of...
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Blood metabolites and chronic kidney disease: a Mendelian randomization study
BackgroundHuman blood metabolites have demonstrated close associations with chronic kidney disease (CKD) in observational studies. Nonetheless, the...
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Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling
Many studies have reported metabolomic analysis of different bio-specimens from Parkinson’s disease (PD) patients. However, inconsistencies in...
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Cancer metabolites: promising biomarkers for cancer liquid biopsy
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that...
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Secondary Metabolites of Plant Origin in Parasitic Manifestations
Malaria, leishmaniasis, and kala-azar are three major parasitic diseases affecting major population of the world but still remain as neglected...
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Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke
BackgroundStroke is a common neurological disorder that disproportionately affects middle-aged and elderly individuals, leading to significant...
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Serum Aromatic Microbial Metabolites as Biological Markers in Intensive Care
Thanks to modern technical solutions and advances in the field of metabolomic research, it has become possible to search for new biomarkers among...
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Metabolites from Fungi: A Promising Source of Lead Compounds Against Cancer
The diversity of fungi represents a fabulous and remarkable asset of sources of bioactive compounds with vast potential for pharmaceutical...
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Associations of gut microbiome with endogenous estrogen levels in healthy postmenopausal women
PurposeThe gut microbiome is a potentially important contributor to endogenous estrogen levels after menopause. In healthy postmenopausal women, we...
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Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls
BackgroundMetabolomics is a potential means for biofluid-based lung cancer detection. We conducted a non-targeted, data-driven assessment of plasma...
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A Narrative Review of the Published Pre-Clinical Evaluations: Multiple Effects of Arachidonic Acid, its Metabolic Enzymes and Metabolites in Epilepsy
Arachidonic acid (AA), an important polyunsaturated fatty acid in the brain, is hydrolyzed by a direct action of phospholipase A 2 (PLA 2 ) or through...
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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses
Objectives . To carry out a clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychoses. Mat...
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Childhood adiposity, serum metabolites and breast density in young women
BackgroundChildhood adiposity is inversely associated with young adult percent dense breast volume (%DBV) and absolute dense breast volume (ADBV),...
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Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
BackgroundThe effects of fermented food consumption on the small intestine microbiome and its role on host homeostasis are largely uncharacterised as...
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13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo
Background13 C tracer analysis is increasingly used to monitor cellular metabolism in vivo and in intact cells, but data interpretation is still the...
