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Challenges of Onco-therapeutics in Early-Onset Colorectal Cancer
The incidence of colorectal cancer among adults aged less than 50 is rising. Patients with early-onset colorectal cancer are more likely to present...
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Comparative characteristics of early-onset vs. late-onset advanced colorectal cancer: a nationwide study in China
BackgroundThe incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age of 50 years) has been increasing around the...
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The incidence of early onset colorectal cancer in Aotearoa New Zealand: 2000–2020
BackgroundThe incidence of early-onset colorectal cancer (EOCRC), diagnosed before age 50, has been rising in many countries in the past few decades....
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A mixed methods evaluation of the unmet needs of early-onset colorectal cancer survivors
PurposeThe incidence of colorectal cancer (CRC) is rising in people under age 50 (early-onset). Early-onset survivors face CRC during a critical...
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A novel nomogram based on cell cycle-related genes for predicting overall survival in early-onset colorectal cancer
BackgroundAlthough the incidence of late-onset colorectal cancer (LOCRC) has decreased, the incidence of early-onset colorectal cancer (EOCRC) is...
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Identification of specific susceptibility loci for the early-onset colorectal cancer
BackgroundThe incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic...
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Association between metabolic syndrome and early-stage colorectal cancer
BackgroundAccumulating studies have suggested metabolic syndrome (MetS) contributed to colorectal cancer (CRC) development. However, advanced CRC...
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SMAD4 Gene Analysis in Patients with Early Onset Colorectal Cancer: A Pilot Study
AbstractIn colorectal cancer (CRC), inactivation of SMAD4 occurs early in the disease development and SMAD4 represents one of key driver genes in...
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Colorectal Cancer
Carcinomas of the colon and rectum (colorectal cancer, CRC) are among the most prevalent cancers worldwide. Colorectal cancers develop through a...
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Colorectal Cancer in North-Eastern Iran: a retrospective, comparative study of early-onset and late-onset cases based on data from the Iranian hereditary colorectal cancer registry
BackgroundThe incidence rate of colorectal cancer (CRC) is increasing among patients below 50 years of age. The reason for this is unclear, but could...
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Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial
BackgroundThe early-onset rectal cancer with rapidly increasing incidence is considered to have distinct clinicopathological and molecular profiles...
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Sexual dysfunction among early-onset colorectal cancer survivors: Sex-specific correlates of sexual health discussions between patients and providers
PurposeTo examine the prevalence of female sexual dysfunction (FSD), male erectile dysfunction (ED), and the prevalence and correlates of sexual...
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Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database
BackgroundAntibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an...
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A risk scoring system to predict the individual incidence of early-onset colorectal cancer
BackgroundThe incidence of early-onset colorectal cancer (EOCRC) is increasing at an alarming rate and further studies are needed to identify risk...
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The TEOGIC study project: a comprehensive characterization of early onset gastrointestinal cancer in the Northern area of Spain
BackgroundGastrointestinal cancers represent one of the most prevalent diseases worldwide. Strikingly, the incidence of Early Onset Gastrointestinal...
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Germline NPAT inactivating variants as cause of hereditary colorectal cancer
Two independent exome sequencing initiatives aimed to identify new genes involved in the predisposition to nonpolyposis colorectal cancer led to the...
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Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and Personalized Treatment
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide as per GLOBOCAN 2020. One out of five patients is diagnosed...
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Clinical implications of genetic testing in familial intermediate and late-onset colorectal cancer
The genetic background of familial, late-onset colorectal cancer (CRC) (i.e., onset > age 50 years) has not been studied as thoroughly as other...
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Multi-Omics Data Analysis for Cancer Research: Colorectal Cancer, Liver Cancer and Lung Cancer
Cancer is a multifactorial disease caused by the malfunction and modification of numerous biological entities, including genes, proteins, mRNAs,...
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Role of Circulating Tumor DNA in Colorectal Cancer
Colorectal cancer (CRC) is a very common gastrointestinal tumor, ranking second in the global cause of cancer death. Because of the invasive nature...