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Challenges of Onco-therapeutics in Early-Onset Colorectal Cancer

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Gastrointestinal Cancers: An Interdisciplinary Approach

Part of the book series: Interdisciplinary Cancer Research ((ICR,volume 4))

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Abstract

The incidence of colorectal cancer among adults aged less than 50 is rising. Patients with early-onset colorectal cancer are more likely to present with advanced disease stage with requirements for multimodal treatment. Younger patients appear to have higher rates of treatment-related toxicities, giving rise to unique challenges for these patients. The impact of treatment-related morbidity on quality of life can be overlooked. Survivorship issues are increasingly relevant owing to the potential for long-term survival following treatment. Striking a balance between treating early-onset colorectal cancer while preserving bowel, bladder, sexual function, and fertility is challenging yet imperative.

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  1. Centre for Colorectal Disease, St Vincent’s University Hospital, Dublin, Ireland

    Katie Doogan, Alexandra M. Zaborowski & Des C. Winter

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  1. Katie Doogan
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  1. Department of Clinical Immunology, Karolinska Institutet, Stockholm, Sweden

    Nima Rezaei

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Doogan, K., Zaborowski, A.M., Winter, D.C. (2023). Challenges of Onco-therapeutics in Early-Onset Colorectal Cancer. In: Rezaei, N. (eds) Gastrointestinal Cancers: An Interdisciplinary Approach. Interdisciplinary Cancer Research, vol 4. Springer, Cham. https://doi.org/10.1007/16833_2023_148

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