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Dual Efficacy of a Catalytic Anti-Oligomeric Aβ42 scFv Antibody in Clearing Aβ42 Aggregates and Reducing Aβ Burden in the Brains of Alzheimer’s Disease Mice
One of the primary pathological mechanisms underlying Alzheimer’s disease (AD) is the deposition of amyloid β-protein (Aβ42) aggregates in the brain....
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Assessing Oligomerization Status of Mitochondrial OXPHOS Complexes Via Blue Native Page
Mitochondrial metabolism plays key roles in pathologies such as cancer. The five complexes of the oxidative phosphorylation (OXPHOS) system are...
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Insights on the dynamic behavior of protein disulfide isomerase in the solution environment through the SAXS technique
The dynamic behavior of Protein Disulfide Isomerase (PDI) in an aqueous solution environment under physiologically active pH has been experimentally...
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An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting
The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade....
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Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly neutralizing antibodies (bNAbs) is hindered by extensive sequence...
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USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with chaperonins, and promotes secretion of...
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Application of Cryoelectron Microscopy in Antiviral Research
In the last decade, single-particle reconstruction from cryoelectron micrographs has been established as a powerful technique for generating...
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Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have...
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Small-Angle Neutron Scattering of RNA–Protein Complexes
Small-angle neutron scattering (SANS) provides structural information on biomacromolecules and their complexes in dilute solutions at the nanometer...
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Structural basis of NLR activation and innate immune signalling in plants
Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) that recognize the presence of pathogens and initiate innate immune...
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A Self-Similarity Logic May Shape the Organization of the Nervous System
From the morphological point of view, the nervous system exhibits a fractal, self-similar geometry at various levels of observations, from single...
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Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease
BackgroundLow-intensity light can decelerate neurodegenerative disease progression and reduce amyloid β (Aβ) levels in the cortex, though the...
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Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
In addition to constituting the genetic material of an organism, DNA is a tracer for the recognition of foreign pathogens and a trigger of the innate...
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Changes in Targets as an Explanation for Drug Resistance in Epilepsy
Drug resistance in epilepsy is a condition that limits the control of seizure activity. The drug target hypothesis postulates changes in those...
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NMR Methods for Characterization of Glycosaminoglycan–Chemokine Interactions
Humans express around 50 chemokines that play crucial roles in human pathophysiology from combating infection to immune surveillance by directing and...
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Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity
BackgroundAlzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems that monitor neuronal...
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How location and cellular signaling combine to activate the NLRP3 inflammasome
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile...
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Dual roles of UPRer and UPRmt in neurodegenerative diseases
The unfolded protein response (UPR) is a cellular stress response mechanism induced by the accumulation of unfolded or misfolded proteins. Within the...
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Calcium Sensors of Neurotransmitter Release
Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous)....
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Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS): A New Axis in Neuronal Degeneration and Regeneration
Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS) are dynamic structures whose physiological interaction is vital to direct life and death of...
