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Dose-response relationship between volume base dose and tumor local control in definitive radiotherapy for vaginal cancer
ObjectiveThis study aimed to establish the dose-response relationship between volume base dose and tumor local control for vaginal cancer, including...
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Dose response relationship between breast cancer and somatotypes during childhood: a systematic review and meta-analysis
ObjectivesThis study aims to evaluate the relationship between breast cancer and somatotypes during early life by meta-analysis and give the...
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Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their...
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Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast
BackgroundThe human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the...
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Serum Uric Acid Levels and Outcome of Acute Ischemic Stroke: a Dose–Response Meta-analysis
Previous meta-analyses have reported conflicting results regarding the relationship between baseline uric acid (UA) levels and acute ischemic stroke...
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Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than...
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Assessing Dose-Exposure–Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach
ObjectivesMiltefosine is the first and only oral medication to be successfully utilized as an antileishmanial agent. However, the drug is associated...
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Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review
The analysis of dose–response, concentration–response, and time–response relationships is a central component of toxicological research. A major...
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Fluoride Exposure and Skeletal Fluorosis: a Systematic Review and Dose-response Meta-analysis
Purpose of ReviewWe performed a systematic review and meta-analysis on the relation between fluoride exposure and skeletal fluorosis (SF) using a...
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The effect of time before diagnosis and treatment on colorectal cancer outcomes: systematic review and dose–response meta-analysis
BackgroundThis systematic review and meta-analysis aimed to evaluate existing evidence on the relationship between diagnostic and treatment intervals...
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A Credibility Assessment Plan for an In Silico Model that Predicts the Dose–Response Relationship of New Tuberculosis Treatments
Tuberculosis is one of the leading causes of death in several develo** countries and a public health emergency of international concern. In Silico ...
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Gene expression signature predicts radiation sensitivity in cell lines using the integral of dose–response curve
BackgroundAlthough substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately...
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Dose–Response Relationship and Extrapolation in Toxicology: Mechanistic and Statistical Considerations
Controversy on toxicological dose–response relationships and extrapolation of an incidence to low dose can be the consequence of misleading data...
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Dose-response meta-analysis on urate, gout, and the risk for Parkinson’s disease
The relationship between Parkinson’s disease (PD) and urate or gout has attracted significant interest in recent years, but the results were...
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Antibody induction and immune response in nasal cavity by third dose of SARS-CoV-2 mRNA vaccination
BackgroundThe mucosa serves as the first defence against pathogens and facilitates the surveillance and elimination of symbiotic bacteria by mucosal...
