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Unravelling the Metal Sensing Activity of a Biologically Relevant Fluorescent Crown Ether: A Unified Experimental and Theoretical Study
1,4-dihydropyridines (DHPs) are biologically active. 1,4-DHP analogs with appropriate substituents also show characteristic fluorescence activity....
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Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives
The novel sulfonamide substitute 1,4-dihydropyridine derivatives were synthesized by the method of Hantzsch reaction. They have been characterized by...
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The pharmacokinetics and safety of lidocaine in liver cancer patients undergoing hepatic resection
PurposeThe purpose of this study was to explore the pharmacokinetics (PK) characteristics and safety of continuous lidocaine infusion during...
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The impact of progredient vessel and tissue stiffening for the development of metabolic syndrome
Established risk factors for the metabolic syndrome as diabetes and arterial hypertension are believed to be the cause of arteriosclerosis and...
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Treatment of Ischemic Heart Disease
Ischemic heart disease is one of the most dreaded clinical conditions since the mortality and morbidity rates associated with it are very high. It is...
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Antihypertensive Agents
Nearly 1/6th of the world population are affected with elevated blood pressure due to various etiology. Pharmacologically, hypertension can be...
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C-subfamily ATP binding cassette transporters extrude the calcium fluorescent probe fluo-4 from a cone photoreceptor cell line
Whole transcriptome sequencing has revealed the existence of mRNAs for multiple membrane transporters in photoreceptors. Except for ATP binding...
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Lercanidipine alleviates doxorubicin-induced lung injury by regulating PERK/CHOP and Bax/Bcl 2/Cyt c pathways
Doxorubicin (DOX), which is used to treat various cancers and hematological malignancies, has limited therapeutic application due to its toxicity in...
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Refractory Shock from Amlodipine Overdose Overcomed with Hyperinsulinemia
Intoxication from calcium channel blockers exhibits almost 50% mortality rates. Amlodipine is a long-acting dihydropyridine and inappropriate dosage...
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Central and peripheral contributions of T-type calcium channels in pain
Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among...
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Synergistic Herb Interactions with Cardiovascular Drugs
Cardiovascular diseases (CVDs) are one of the prime reasons of mortality globally. Around 17.9 million deaths were witnessed in 2019 due to CVDs, and...
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JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin Expression
Traumatic brain injury (TBI) is considered a public health problem and is often related to motor and cognitive disabilities, besides behavioral and...
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Ionic Liquids: Design and Applications
In this chapter, which is divided in two parts, several aspects concerning ionic liquids are discussed. Part one contains a brief history of the...
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Bioanalytical Assays: Gas Chromatography (GC)
The quantitative determination of analytes in biological matrices such as blood and urine is called bioanalysis. Bioanalysis regulatory authorities...