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CFI: a VR motor rehabilitation serious game design framework integrating rehabilitation function and game design principles with an upper limb case
Virtual reality (VR) Rehabilitation holds the potential to address the challenge that patients feel bored and give up long-term rehabilitation...
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Optimal design of synthetic circular RNAs
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently linked via back-splicing. Due to their versatility, the need to...
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Mentoring for INnovative Design Solutions (MINDS): Key Design Considerations and Collaborative Teamwork across Universities for Clinical Translation
The main purpose of this paper is to share the Mentoring for INnovative Design Solutions (MINDS) Scholars Program developed by Alpha Eta Mu Beta, the...
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Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads Using Box–Behnken Design and Desirability Function for Colon Targeting
PurposeThe main objective was to develop and optimize a multiparticulate system of 5-fluorouracil through the Box–Behnken design (BBD) and...
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Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation
PurposeBepotastine besilate, a second-generation antihistamine commonly prescribed to treat allergic rhinitis and urticarial/pruritus, has a short...
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Empowering Students in Medical Device Design: An Interdisciplinary Soft Robotics Course
Experiential learning in biomedical engineering curricula is a critical component to develo** graduates who are equipped to contribute to technical...
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Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly develo** field in which the delivery of genetic information in the form of mRNA is used to direct therapeutic...
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Insilico design of an allosteric modulator targeting the protein–protein interaction site of 3 Phosphoinositide dependent Kinase-1: design, synthesis and biological activity
The signalling pathways in human cells mostly rely on protein–protein interactions (PPI) for their function. Such a PPI site in 3 Phosphoinositide...
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RNAi-based drug design: considerations and future directions
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming pharmaceutical...
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Leveraging an Open-Access Digital Design Notebook for Graduate Biomedical Engineering Education in Nigeria
Amidst the dual challenges of an eight-month university closure from nationwide public university strikes in Nigeria and the lingering impacts of the...
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Human-centered design of a novel soft exosuit for post-stroke gait rehabilitation
BackgroundStroke remains a major cause of long-term adult disability in the United States, necessitating the need for effective rehabilitation...
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A Jigsaw Approach to Strategic Considerations in Biomedical Engineering Design and Innovation
We have implemented a jigsaw framework in our biomedical engineering capstone design course by overlaying strategic consideration groups across our...
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API Quality by Design
The pharmaceutical sector is always adapting, and so must the idea and practise of quality by design (QbD). In regulatory submissions, active...
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Design, Synthesis, Application and Research Progress of Fluorescent Probes
Fluorescent probes are sensitive, selective, nontoxic in detection and thus provided a new solution in biomedical, environmental monitoring, and food...
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Design an Intervention Study
Randomized controlled trials are commonly designed to compare the effectiveness of treatments in rheumatoid arthritis (RA). In a clinical trial...
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Design considerations for patient-specific bone fixation plates: a literature review
In orthopedic surgery, patient-specific bone plates are used for fixation when conventional bone plates do not fit the specific anatomy of a patient....
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Analytical Quality by Design
QbD applied to analytical procedure development is termed as Analytical Quality by Design (AQbD). ICH Q14 encompasses the approach of AQbD....
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Quality by Design Framework Applied to GMMA Purification
In recent years, Generalized Modules for Membrane Antigens (GMMA) have received increased attention as an innovative vaccine platform against...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Material design for oral insulin delivery
Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are...
