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Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resulting from oligodendrocyte loss...
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Bifidobacterium breve Probiotic Compared to Lactobacillus casei Causes a Better Reduction in Demyelination and Oxidative Stress in Cuprizone-Induced Demyelination Model of Rat
Despite the anatomical separation, strong evidence suggested a bidirectional association between gut microbiota and central nervous system....
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Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation
The treatment of immunomodulation in multiple sclerosis (MS) can alleviate the severity and relapses. However, it cannot improve the neurological...
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IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy
Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located...
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Olaparib Attenuates Demyelination and Neuroinflammation in an Organotypic Slice Culture Model of Metachromatic Leukodystrophy
Metachromatic leukodystrophy (MLD) is a severe demyelinating, autosomal recessive genetic leukodystrophy. The disease is underpinned by mutations in...
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Inducible nitric oxide synthase deficiency promotes murine-β-coronavirus induced demyelination
BackgroundMultiple sclerosis (MS) is characterized by neuroinflammation and demyelination orchestrated by activated neuroglial cells, CNS...
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Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
BackgroundCystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demyelination and...
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Spectrum of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
Background and purposeAlthough rare, neurological adverse events have been reported post-COVID-19 vaccination. This study reports 16 patients...
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Microglial Neuroinflammation-Independent Reversal of Demyelination of Corpus Callosum by Arsenic in a Cuprizone-Induced Demyelinating Mouse Model
Demyelination is the loss of myelin in CNS, resulting in damaged myelin sheath. Oxidative stress and neuroinflammation play a key role in inducing...
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Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus
Multiple sclerosis (MS) is a neurodegenerative disease characterized by the demyelination of nerves, axonal damage, and neuroinflammation. Cognition...
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Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
BackgroundMicroglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause...
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Autoimmune demyelination alters hypothalamic transcriptome and endocrine function
The hypothalamus is a brain structure that is deputed to maintain organism homeostasis by regulating autonomic function and hormonal production as...
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Hexahydrocurcumin attenuated demyelination and improved cognitive impairment in chronic cerebral hypoperfusion rats
Age-related white matter lesions (WML) frequently present vascular problems by decreasing cerebral blood supply, resulting in the condition known as...
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Roles of Adenosine Receptor (subtypes A1 and A2A) in Cuprizone-Induced Hippocampal Demyelination
Hippocampal demyelination in multiple sclerosis (MS) has been linked with cognitive deficits, however, patients could benefit from treatment that...
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Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination
Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell...
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Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function
The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin (CAP), the main component of...
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Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
BackgroundAbnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to...
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The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives
Recent evidence suggests that the glucagon-like peptide-1 receptor (GLP-1R) agonists have neuroprotective activities in the CNS in animal models of...
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Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination
BackgroundTriggering receptor expressed on myeloid cells 2 (Trem2) plays a protective role in neurodegenerative diseases. By contrast, Trem2...
