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Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks
Ischemic stroke (IS) is a complex neurological disorder characterized by the sudden disruption of blood flow to the brain, leading to severe and...
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Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis
ObjectiveMice are routinely utilized as animal models of drug-induced liver injury (DILI), however, there are significant differences in the...
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Identification of Potential Biomarkers for Major Depressive Disorder: Based on Integrated Bioinformatics and Clinical Validation
Major depressive disorder (MDD) is a severe mental illness characterized by a lack of objective biomarkers. Mounting evidence suggests there are...
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Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice
BackgroundHeart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by...
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Analysis of Differentially Expressed Genes between Paroxysmal and Persistent Atrial Fibrillation
AbstractAtrial fibrillation is one of the most common arrhythmias in adults. There is a significant difference in the curative effect between...
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Exosome-Mediated Communication in Thyroid Cancer: Implications for Prognosis and Therapeutic Targets
Thyroid cancer (THCA) is one of the most common malignancies of the endocrine system. Exosomes have significant value in performing molecular...
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Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study
Trigeminal neuralgia (TN) brings a huge burden to patients, without long-term effective treatment. This study aimed to explore the differentially...
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Identification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing
BackgroundObstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the...
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Transcriptome analysis of Kunming mice responses to the bite of Xenopsylla cheopis
BackgroundFlea bites could trigger a series of complex molecular responses in the host. However, our understanding of the responses at the molecular...
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Single-Cell RNA Sequencing Analysis of Microglia Dissected the Energy Metabolism and Revealed Potential Biomarkers in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease, accompanied by the gradual loss of motor neuron, even life-threatening....
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Transcriptomics reveals dynamic changes in the “gene profiles” of rat supraspinatus tendon at three different time points after diabetes induction
ObjectiveThere is increasing evidence that type 2 diabetes mellitus (T2DM) is an independent risk factor for the occur of tendinopathy. Therefore,...
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Genetic Programs Between Steroid-Sensitive and Steroid-Insensitive Interstitial Lung Disease
The effectiveness of corticosteroids (GCs) varies greatly in interstitial lung diseases (ILDs). In this study, we aimed to compare the gene...
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Mitochondria-Related Gene MAOB is a Key Biomarker of Osteoarthritis and Inhibition of Its Expression Reduces LPS-induced Chondrocyte Damage
The mitochondria are an important organelle in cells responsible for producing energy, and its abnormal function is closely related to the occurrence...
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Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function
DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics...
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Sphingolipids as Oxygen Sensors and Major Orchestrators of Cellular Responses to Hypoxia
Hypoxia, the drop in tissue oxygenation, holds a poor prognostic value in different clinicopathologic settings. In solid tumors, hypoxia induces a...
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MALAT1-regulated gene expression profiling in lung cancer cell lines
BackgroundNon-small cell lung cancer (NSCLC) is the most common type of lung cancer and has a poor prognosis. Identifying biomarkers based on...
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Identification of Potential Neddylation-related Key Genes in Ischemic Stroke based on Machine Learning Methods
Ischemic stroke (IS) is a complex neurological disease that can lead to severe disability or even death. Understanding the molecular mechanisms...
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to...
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Exploring Pyroptosis-related Signature Genes and Potential Drugs in Ulcerative Colitis by Transcriptome Data and Animal Experimental Validation
Ulcerative colitis (UC) is an idiopathic, relapsing inflammatory disorder of the colonic mucosa. Pyroptosis contributes significantly to UC. However,...
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Meta-analysis to Unravel Core Transcriptomic Responses in Penaeus vannamei Exposed to Biotic and Abiotic Stresses
Shrimp farming, a dominant economic activity in coastal areas, is affected by different abiotic and biotic stress factors. These stressors, under...
