Search
Search Results
-
An Approach to Segment Nuclei and Cytoplasm in Lung Cancer Brightfield Images Using Hybrid Swin-Unet Transformer
PurposeSegmentation of nuclei and cytoplasm in cellular images is essential for estimating the prognosis of lung cancer disease. The detection of...
-
Inheritance through the cytoplasm
Most heritable information in eukaryotic cells is encoded in the nuclear genome, with inheritance patterns following classic Mendelian segregation....
-
Toxic Effect of Zinc Ions Is Accompanied by Acidification of the Cytoplasm in Cultured Rat Cerebellar Granule Neurons
Addition of 0.07 mM zinc ions to the culture medium induced death of cerebellar granule neurons. This was preceded by a decrease in intracellular pH...
-
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
BackgroundNoncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various...
-
Bacillus phage phi18-2 is a novel temperate virus with an unintegrated genome present in the cytoplasm of lysogenic cells as a linear phage-plasmid
Bacillus subtilis is a Gram-positive bacterium that is widely used in fermentation and in the pharmaceutical industry. Phage contamination...
-
HMGB1 accumulation in cytoplasm mediates noise-induced cochlear damage
Damage-associated molecular pattern molecules (DAMPs) play a critical role in mediating cochlear cell death, which leads to noise-induced hearing...
-
Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
BackgroundMetastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising...
-
INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma
BackgroundIncreasing evidence has suggested inositol polyphosphate 5-phosphatase family contributes to tumorigenesis and tumor progression. However,...
-
In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in the membrane for uniaxial substrate stretch
Existing in silico models for single cell mechanics feature limited representations of cytoskeletal structures that contribute substantially to the...
-
The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm
Phenylephrine (PE) is a canonical α 1 -adrenoceptor-selective agonist. However, unexpected effects of PE have been observed in preclinical and clinical...
-
GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear...
-
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease
Several conserved nuclear RNA binding proteins ( sut-1, sut-2, and parn-2 ) control tau aggregation and toxicity in C. elegans , mice, and human cells....
-
Kapβ2 Inhibits Perioperative Neurocognitive Disorders in Rats with Mild Cognitive Impairment by Reversing the Nuclear-Cytoplasmic Mislocalization of hnRNPA2/B1
Harmful stimuli trigger mutations lead to uncontrolled accumulation of hnRNPA2/B1 in the cytoplasm, exacerbating neuronal damage. Kapβ2 mediates the...
-
LL-37-dsRNA Complexes Modulate Immune Response via RIG-I in Oral Keratinocytes
Recognition of nucleic acids as pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) promotes an...
-
Nuclear Export of mRNAs with Disease Pathogenesis and Therapeutic Implications
In eukaryotes, RNA polymerase II genes are transcribed to mRNAs, processed in the nucleus, and then exported to the cytoplasm through the nuclear...
-
Phosphorylation of EZH2 differs HER2-positive breast cancer invasiveness in a site-specific manner
HER2-positive breast cancer (BC) invasiveness and drug-resistance issue is the critical treatment obstacle recently. We investigated the total and...
-
Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Pathological forms of Tar-DNA binding protein-43...
-
Connexin-Containing Vesicles for Drug Delivery
Connexin is a transmembrane protein present on the cell membrane of most cell types. Connexins assemble into a hexameric hemichannel known as...
-
Application of image-recognition techniques to automated micronucleus detection in the in vitro micronucleus assay
BackgroundAn in vitro micronucleus assay is a standard genotoxicity test. Although the technique and interpretation of the results are simple, manual...
-
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
BackgroundThe key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43...
