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A cost-benefit analysis of genetic screening test for breast cancer in Iran
BackgroundThis study aimed to evaluate the implementation of the population- and family history (FH) -based screening for BReast CAncer (BRCA) in...
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Abbott realtime MTB assay for detecting Mycobacterium tuberculosis complex in respiratory specimens: a cost-benefit analysis
PurposeMolecular screening for Mycobacterium tuberculosis (MTB) can lead to rapid empirical treatment inception and reduce hospitalization time and...
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Incremental net benefit of lipid-lowering therapy with PCSK9 inhibitors: a systematic review and meta-analysis of cost-utility studies
IntroductionProprotein convertase subtilisin/kexin 9 inhibitors (PCSK9i) are monoclonal antibodies that lower lipid levels. Although several...
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Individualized quality of life benefit and cost-effectiveness estimates of proton therapy for patients with oropharyngeal cancer
BackgroundProton therapy is a promising advancement in radiation oncology especially in terms of reducing normal tissue toxicity, although it is...
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Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology
In this commentary, using existing clinical trial data and FDA approvals we propose that there is currently a critical need for an appropriate...
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Cost-effectiveness analysis of molecular testing in minimally invasive samples to detect endometrial cancer in women with postmenopausal bleeding
IntroductionNew approaches are being developed to early detect endometrial cancer using molecular biomarkers. These approaches offer high...
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Updated cost-effectiveness analysis of lung cancer screening for Australia, capturing differences in the health economic impact of NELSON and NLST outcomes
BackgroundA national, lung cancer screening programme is under consideration in Australia, and we assessed cost-effectiveness using updated data and...
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Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data
The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung...
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Feasibility of novel adult tuberculosis vaccination in South Africa: a cost-effectiveness and budget impact analysis
Early trials of novel vaccines against tuberculosis (TB) in adults have suggested substantial protection against TB. However, little is known about...
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Serplulimab Plus Chemotherapy vs Chemotherapy for Treatment of US and Chinese Patients with Extensive-Stage Small-Cell Lung Cancer: A Cost-Effectiveness Analysis to Inform Drug Pricing
BackgroundSerplulimab is a potential valuable therapy, while patients, physicians, and decision-makers are uncertain about the cost-effectiveness of...
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Cost-utility analysis of a structured medication review compared to usual care in Parkinson’s disease
PurposeFor controlling symptoms in Parkinson’s disease (PD) together with treating additional comorbidities, patients often face complex medication...
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Early-stage economic analysis of research-based comprehensive genomic sequencing for advanced cancer care
Genomic research is driving discovery for future population benefit. Limited evidence exists on immediate patient and health system impacts of...
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Design and analysis of polycentric prosthetic knee with enhanced kinematics and stability
This paper describes a continuation of earlier work using the finite element method to conduct an engineering failure analysis of an existing...
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Anatomic versus non-anatomic resection for early-stage intrahepatic cholangiocarcinoma: a propensity score matching and stabilized inverse probability of treatment weighting analysis
BackgroundRadical resection is still the most cost-effectiveness curative strategy for intrahepatic cholangiocarcinoma (ICC), but it remains...
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CT ventilation image-guided helical Tomotherapy at sparing functional lungs for locally advanced lung cancer: analysis of dose-function metrics and the impact on pulmonary toxicity
PurposeCT ventilation image (CTVI)-guided radiotherapy that selectively avoids irradiating highly-functional lung regions has potential to reduce...
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Pharmacoeconomic Analysis Methods
In the last years, the growing interest of healthcare professionals, policy-makers, and other stakeholders in enlarging the role of economic...
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Cost-effectiveness analysis of first-line treatment with crizotinib in ROS1-rearranged advanced non-small cell lung cancer (NSCLC) in Canada
IntroductionWhile no direct comparative data exist for crizotinib in ROS1+ non-small cell lung cancer (NSCLC), studies have suggested clinical...
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Applications of Model-Based Meta-Analysis in Drug Development
Model-based meta-analysis (MBMA) is a quantitative approach that leverages published summary data along with internal data and can be applied to...
