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Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks
The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural...
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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical...
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Neuron–Glia-Ratio-Like Approach Evidenced for Limited Variability and In-Aggregate Circadian Shifts in Cortical Cell-Specific Transcriptomes
Regardless of shifts in levels of individual transcripts, it remains elusive whether natural variability in cell-specific transcriptomes within the...
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Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear how convergent biological processes in affected individuals...
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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germinal zone of the embryonic...
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Single-neuron analysis of dendrites and axons reveals the network organization in mouse prefrontal cortex
The structures of dendrites and axons form the basis for the connectivity of neural network, but their precise relationship at single-neuron level...
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Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across...
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Single-neuron projectome of mouse prefrontal cortex
Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain activity. However, the whole-brain organization of PFC...
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Whole-brain Map** of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice
The orbitofrontal cortex (ORB), a region crucial for stimulus-reward association, decision-making, and flexible behaviors, extensively connects with...
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Neuron–oligodendroglial interactions in health and malignant disease
Experience sculpts brain structure and function. Activity-dependent modulation of the myelinated infrastructure of the nervous system has emerged as...
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Generation of Cerebral Cortical Neurons from Human Pluripotent Stem Cells in 3D Culture
Human forebrain cortical neurons are essential for fundamental functions like memory and consciousness. Generation of cortical neurons from human...
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Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
The axon initial segment (AIS) is a highly specialized axonal compartment where the action potential is initiated. The heterogeneity of AISs has been...
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Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells
Corticothalamic pathways, responsible for the top-down control of the thalamus, have a canonical organization such that every cortical region sends...
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Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis
Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated...
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A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice
Exploring the relationship between neuronal dynamics and ethologically relevant behaviour involves recording neuronal-population activity using...
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Morphine-Driven m6A Epitranscriptomic Neuroadaptations in Primary Cortical Cultures
Opioid overdose is the leading cause of accidental death in the United States and remains a major public health concern, despite significant...
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A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization...
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In vivo cortical diffusion imaging relates to Alzheimer’s disease neuropathology
BackgroundThere has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than...
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Development, wiring and function of dopamine neuron subtypes
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are...
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Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
The cingulate gyrus, as a prominent part of the human limbic lobe, is involved in the integration and regulation of complex emotional, executive,...
