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Analysis of FOXP3 DNA Methylation Patterns to Identify Functional FOXP3+ T-Cell Subpopulations
Human regulatory CD4+CD25+FOXP3+ T cells (Tregs) are involved in the suppression of immune responses and play important roles in the maintenance of...
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Genome-Wide Principles of Gene Regulation
In this chapter, we will discuss about new principles of genome-wide gene regulation as obtained through data from Big Biology projects like ENCODE,...
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Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content
BackgroundHypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer...
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Advances in single-cell omics and multiomics for high-resolution molecular profiling
Single-cell omics technologies have revolutionized molecular profiling by providing high-resolution insights into cellular heterogeneity and...
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Navigating the pitfalls of map** DNA and RNA modifications
Chemical modifications to nucleic acids occur across the kingdoms of life and carry important regulatory information. Reliable high-resolution...
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Single-cell multiomics: technologies and data analysis methods
Advances in single-cell isolation and barcoding technologies offer unprecedented opportunities to profile DNA, mRNA, and proteins at a single-cell...
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Evaluating Methylation of the Oxytocin Receptor Gene and the Oxytocin Intergenic Region
Oxytocin and its paralogue, vasopressin, are widely studied biomarkers in relation to pregnancy and birth, maternalMaternal behaviour and social...
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Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease are controlled by cis -regulatory elements (CREs), such as...
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Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing
Nanopore sequencing has brought the technology to the next generation in the science of sequencing. This is achieved through research advancing on:...
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DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis
Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow...
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Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
BackgroundPrevious studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as the fundamental...
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DNA Methylation Imputation Across Platforms
In this chapter, we will provide a review on imputation in the context of DNA methylation, specifically focusing on a penalized functional regression...
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Multimodal Omics Approaches to Aging and Age-Related Diseases
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders. An increasing body of...
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Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer
Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious,...
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The applications of DNA methylation as a biomarker in kidney transplantation: a systematic review
BackgroundAlthough kidney transplantation improves patient survival and quality of life, long-term results are hampered by both immune- and...
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Research progress and application of single-cell sequencing in head and neck malignant tumors
Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes the genetic material...
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Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer
BackgroundPrimary or acquired chemoresistance is a key link in the high mortality rate of ovarian cancer. There is no reliable method to predict...
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Main Existing Datasets for Open Brain Research on Humans
Recent advances in technology have made possible to quantify fine-grained individual differences at many levels, such as genetic, genomics, organ...
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DNA Methylation Analysis
DNA methylation is a process by which methyl groups are added to cytosine or adenine. DNA methylation can change the activity of the DNA molecule...