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Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure...
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Electroacupuncture promotes remyelination and alleviates cognitive deficit via promoting OPC differentiation in a rat model of subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating cerebral vascular disease which causes neurological deficits including long-term cognitive deficit....
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Cognitive control enhancement in attention deficit hyperactivity disorder (ADHD) and neurotypical individuals
Cognitive control, which has been localized to the right inferior frontal gyrus (rIFG) based on functional imaging and brain lesion studies, is...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant...
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Eye movement characteristics in male patients with deficit and non-deficit schizophrenia and their relationships with psychiatric symptoms and cognitive function
BackgroundThe cognitive impairment pattern of deficit schizophrenia (DS) is centered on an impaired attention function. Previous studies have...
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Effect of BRD4 Inhibitor on Cognitive Deficit and c-Fos /BDNF level in rats with Alzheimer's disease
This study evaluated the effect of intra-hippocampal injection of JQ1 on cognitive deficiency and protein level of c-Fos and brain-derived...
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Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment
Mounting evidence shows that dietary intake of fruits with polyphenols is beneficial to improve impaired memory functions. This study explored the...
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Fingolimod Alleviates Cognitive Deficit in Type 2 Diabetes by Promoting Microglial M2 Polarization via the pSTAT3-jmjd3 Axis
Sphingosine receptors (S1PRs) are implicated in the progression of neurodegenerative diseases and metabolic disorders like obesity and type 2...
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Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
BackgroundDemyelinating diseases in central nervous system (CNS) are a group of diseases characterized by myelin damage or myelin loss. Transforming...
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STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation
Sleep deprivation (SD) has been associated with several adverse effects, including cognitive deficit. Emerging evidence suggests microglia-associated...
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Morus Alba Fruit Extract and its Fractions Ameliorate Streptozotocin Induced Cognitive Deficit in Mice via Modulating Oxidative and Cholinergic Systems
Increased oxidative stress and acetylcholinesterase (AChE) activity are key pathological characters contributing to the memory disorders. Thus, drugs...
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Auranofin-loaded PLGA nanoparticles alleviate cognitive deficit induced by streptozotocin in rats model: modulation of oxidative stress, neuroinflammatory markers, and neurotransmitters
Alzheimer’s disease remains an unsolved neurological puzzle with no cure. Current therapies offer only symptomatic relief, hindered by limited uptake...
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Relationship between DNA Methylation within the YJEFN3 Gene and Cognitive Deficit in Schizophrenia Spectrum Disorders
AbstractThe study investigated methylation of each cytosine within a fragment of the YJEFN3 gene located at one of the index loci of schizophrenia...
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Cognitive Correlates of Risky Decision-Making in Individuals with and without ADHD: A Meta-analysis
This meta-analytic study aims to investigate the cognitive correlates of risky decision-making in individuals with attention-deficit/hyperactivity...
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Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice
The early stages of ageing are a critical time window in which the ability to detect and identify precocious molecular and cognitive markers can make...
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Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations....
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Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
BackgroundExposure to sunlight may decrease the risk of develo** Alzheimer’s disease (AD), and visible and near infrared light have been proposed...
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Gender-related Characteristics of Oxidative Stress Severity and Cognitive Impairment in Patients With Schizophrenia
The gender specificity of the clinical and psychopathological features of schizophrenia is an important factor in this disease. Gender features of...
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A single bout of passive exercise mitigates a mental fatigue-induced inhibitory control deficit
Sustained cognitive effort associated with the psychomotor vigilance task (PVT) increases objective and subjective measures of mental fatigue and...
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Cognitive Dysfunction in COVID-19
We present here an analysis of non-Russian publications illustrating changes in concepts relating to the etiology, pathogenesis, main...