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Maladaptive choices by defeated rats: link between rapid approach to social threat and escalated cocaine self-administration
RationaleIntermittent social defeat stress engenders persistent neuroadaptations and can result in later increased cocaine taking and seeking....
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Social dominance in rats: effects on cocaine self-administration, novelty reactivity and dopamine receptor binding and content in the striatum
RationaleStudies in human and non-human primates demonstrate that social status is an important determinant of cocaine reinforcement. However, it is...
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Tests for Anxiolytic Activity
Definitions in psychopharmacology have been coined by the activity of special compounds or chemical classes found in patients. This is not only true... -
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Tests for Anxiolytic Activity
Definitions in psychopharmacology have been coined by the activity of special compounds or chemical classes found in patients. This is not only true... -
Conditioned Place Preference in Rodents and Humans
Place conditioning is among the most commonly used procedures to assess drug reward in animals. The procedure is used to study acquisition of... -
Some Guidelines for Defining Personality Differences in Rats
Whereas many behavioral studies with rats have been traditionally concerned with tests and/or models attempting to deal with subjects such as... -
Psychotropic and Neurotropic Activity
The effects of drugs on the central and peripheral nervous systems can be easily recognized in normal animals. This does not necessarily mean that... -
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects...
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