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Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models
Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and...
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Dissection of paracrine/autocrine interplay in lung tumor microenvironment mimicking cancer cell-monocyte co-culture models reveals proteins that promote inflammation and metastasis
BackgroundTumor cell-monocyte interactions play crucial roles in sha** up the pro-tumorigenic phenotype and functional output of tumor-associated...
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Studying Monocyte-Myofibroblast Immunomodulation in a 3D Co-culture System
Simple and reproducible 3D cell culture systems that mimic biological interactions within physiological tissues (biomimetics) can provide unique...
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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
BackgroundIntraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that...
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Influence of Remodeled ECM and Co-culture with iPSC-Derived Cardiac Fibroblasts on the Mechanical Function of Micropatterned iPSC-Derived Cardiomyocytes
IntroductionIn native heart tissue, functions of cardiac fibroblasts (CFs) include synthesis, remodeling, and degradation of the extracellular matrix...
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Protein–protein-interaction assay coupled with proteome profiler and immune activation flow cytometry assay validate immune activation in 3D oral cancer-immune co-culture model
Immune evasion is one of the hallmarks of cancer progression. Immunotherapy failed to produce appreciable treatment response in aggressive oral...
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A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies
The intestinal barrier is a complex interface of the human body, possessing the largest contact surface to nutrients and antigens and containing a...
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In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer
BackgroundAs a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in...
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Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model
BackgroundEpidemiological studies have related desert dust events to increased respiratory morbidity and mortality. Although the Sahara is the...
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Culture and Co-culture of Cells for Multi-organ on a Chip
The pre-clinical trials in the drug discovery timeline involve an immense amount of time and money to elucidate the drug responses precisely. Cell...
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Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
To improve the mechanistic screening of reproductive toxicants in chemical-risk assessment and drug development, we have developed a...
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Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system
BackgroundCancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and...
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Tiagabine and zonisamide differentially regulate the glial properties in an astrocyte-microglia co-culture model of inflammation
Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial...
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Adipocyte–Breast Cancer Cell Co-Culture in Transwells
Experiments with cell co-culture systems facilitate investigation of the effects of one cell population on another, when the cells are grown in close...
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RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy to promote drug delivery...
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Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance
BackgroundGemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages in the tumor...
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Microglia-mediated drug substance transfer promotes chemoresistance in brain tumors: insights from an in vitro co-culture model using GCV/Tk prodrug system
BackgroundIt is well known that tumor-associated macrophages (TAMs) play essential roles in brain tumor resistance to chemotherapy. However, the...
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Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling
Apoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion...
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Three-Dimensional Co-Culture Method for Studying Interactions Between Adipocytes, Extracellular Matrix, and Cancer Cells
Three-dimensional (D) culture models are increasingly becoming the model of choice for studying different biological phenomena such as cell–cell...
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Newly developed 3D in vitro models to study tumor–immune interaction
Immunotherapy as a rapidly develo** therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology...
