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Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198
BackgroundCircular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells....
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Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab
BackgroundTriple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely...
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The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different...
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Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major...
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Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for...
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CircRNA (circ)_0007823 Contributes to Triple-Negative Breast Cancer Progression and Cisplatin Resistance via the miR-182-5p/FOXO1 Pathway
Cisplatin (DDP) is used for the clinical management of triple-negative breast cancer (TNBC). However, the development of drug resistance limits its...
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Evaluation of Circ_0000977-Mediated Regulatory Network in Breast Cancer: A Potential Discriminative Biomarker for Triple-Negative Tumors
Previous investigations have revealed that circular RNAs (circRNAs) play pivotal roles in cancer development and progression by participating in...
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Non-coding RNAs as potential therapeutic targets for receptor tyrosine kinase signaling in solid tumors: current status and future directions
This review article presents an in-depth analysis of the current state of research on receptor tyrosine kinase regulatory non-coding RNAs (RTK-RNAs)...
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Extracellular Vesicles as Biomarkers for Cancer
Because of the minimally invasive nature of biofluid collection, extracellular vesicles (EVs) have promising applications in the diagnosis,...
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circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer
BackgroundApproximate 25% HER2-positive (HER2 + ) breast cancer (BC) patients treated with trastuzumab recurred rapidly. However, the mechanisms...
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Circular RNAs’ cap-independent translation protein and its roles in carcinomas
Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and...
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The Role of Non-coding RNAs in Drug Resistance of Cancers
Cancer is a leading cause of mortality in patients worldwide. Some types of cancer treatment are surgery, chemotherapy, radiation therapy, targeted...
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Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy
Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer...
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Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells
Approximately 25% of breast cancer (BC) patients are HER2-positive. Trastuzumab is used as a targeted therapy drug to treat HER2-positive BC...
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Radiogenomic analysis of cellular tumor-stroma heterogeneity as a prognostic predictor in breast cancer
BackgroundThe tumor microenvironment and intercellular communication between solid tumors and the surrounding stroma play crucial roles in cancer...
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Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression
Cancer is the second-leading disease-related cause of global mortality after cardiovascular disease. Despite significant advances in cancer...
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Exosomes as a new frontier of cancer liquid biopsy
Liquid biopsy, characterized by minimally invasive detection through biofluids such as blood, saliva, and urine, has emerged as a revolutionary...
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CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation
Peptides and proteins encoded by noncanonical open reading frames (ORFs) of circRNAs have recently been recognized to play important roles in disease...
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Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression
BackgroundA growing body of evidence indicates that abnormal expression of circular RNAs (circRNAs) plays a crucial role by acting as molecular...
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m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells,...
